Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Reiter, E; Keil, F; Brugger, S; Kalhs, P; Rabitsch, W; Hinterberger, W; Fischer, G; Rosenmayr, A; Haas, O; Volc, B; Lechner, K; Greinix, HT.
Excellent long-term survival after allogeneic marrow transplantation in patients with severe aplastic anemia.
Bone Marrow Transplant. 1997; 19(12):1191-1196
Doi: 10.1038/sj.bmt.1700819
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Between 1982 and 1996, 20 patients (10 male, 10 female) with severe aplastic anemia (SAA) with a median age of 25 years (17-37 years), received grafts from an HLA-identical sibling (n = 17), HLA-identical unrelated donor (n = 2) or identical twin (n = 1). The median time from diagnosis to marrow transplantation (BMT) was 15 months (range 1-96 months). More than half of the patients had received more than 10 units of red blood cells or platelet transfusions prior to BMT. Pretransplant immunosuppression consisted of cyclophosphamide (CY) alone (n = 10), CY in combination with total body irradiation (n = 8), and CY and antithymocyte globulin (n = 2). For graft-versus-host disease (GVHD) prophylaxis methotrexate (MTX) alone (n = 9) or MTX with cyclosporin A (n = 10) were given. One patient died on day 18 after marrow grafting due to infection; all other patients had complete and sustained engraftment (95%). Eight patients developed acute GVHD (42%), nine patients chronic GVHD (53%) including four with extensive disease manifestation. One patient experienced a secondary malignancy 11 years after BMT. Eighteen patients followed for a median of 9.45 years (0.42-14.7 years) have sustained hematological reconstitution and are alive and well with a Karnofsky performance score of at least 90%. Thus, excellent long-term survival and low morbidity make allogeneic or syngeneic BMT the treatment of choice for younger patients with severe aplastic anemia.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Anemia, Aplastic - mortality Anemia, Aplastic - therapy
- Bone Marrow Transplantation - adverse effects Bone Marrow Transplantation - immunology
- Diseases in Twins -
- Family -
- Female -
- Follow-Up Studies -
- Graft Survival -
- Graft vs Host Disease - etiology
- HLA Antigens -
- Humans -
- Living Donors -
- Male -
- Survival Rate -
- Transplantation, Homologous -
- Transplantation, Isogeneic -
- Twins, Monozygotic -
- Find related publications in this database (Keywords)
- aplastic anemia
- allogeneic marrow transplantation
- long-term follow-up