Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Keil, F; Kalhs, P; Haas, OA; Fritsch, G; Reiter, E; Mannhalter, C; Lechner, K; Leitner, G; Greinix, HT.
Relapse of Philadelphia chromosome positive acute lymphoblastic leukaemia after marrow transplantation: sustained molecular remission after early and dose-escalating infusion of donor leucocytes.
Br J Haematol. 1997; 97(1):161-164
Doi: 10.1046/j.1365-2141.1997.262674.x
(- Case Report)
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- We present a patient who underwent sibling allogeneic BMT because of refractory Ph+ve ALL and remained BCR-ABL-positive after marrow grafting. Haemopoietic precursor cells were predominantly BCR-ABL-negative and of donor origin. In T cells an exclusively donor genotype was demonstrated. Despite donor leucocyte infusion (DLI), 20 weeks after BMT BCR-ABL fusion mRNA increased in semiquantitative polymerase chain reaction and leukaemic infiltration of the patient's bone marrow was seen. After a second course of DLI the patient achieved sustained molecular remission but he developed severe graft-versus-host disease (GvHD) and died from bacterial sepsis 9 months after DLI.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Bone Marrow Transplantation - methods
- Fatal Outcome -
- Humans -
- Leukocyte Transfusion - methods
- Male -
- Neoplasm, Residual -
- Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
- Recurrence -
- Transplantation Chimera -
- Transplantation, Homologous -
- Find related publications in this database (Keywords)
- allogeneic marrow transplantation
- Ph+ve ALL
- donor leucocyte infusion