Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gerber, M; Gmeinhart, B; Volc-Platzer, B; Kalhs, P; Greinix, H; Knobler, R.
Complete remission of lichen-planus-like graft-versus-host disease (GVHD) with extracorporeal photochemotherapy (ECP).
Bone Marrow Transplant. 1997; 19(5):517-519
Doi: 10.1038/sj.bmt.1700661
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- A 45-year-old female patient with CML underwent allogeneic BMT and developed two episodes of acute GVHD. The first episode of acute cutaneous GVHD grade II (day +17) responded well to systemic CsA and steroids. During the second episode (around day +60) the patient developed erythroderma (grade III), and subsequently signs of lichen-planus-like GVHD. The patient did not respond to increased dosages of prednisolone and CsA. On day +89 extracorporeal photochemotherapy (ECP) was initiated. After four cycles, a significant improvement of erythroderma and lichen-planus-like lesions was documented, and after 12 cycles, a lasting complete remission was achieved. To our knowledge this is the first report of successful treatment of early-onset, lichen-planus-like GVHD after allogeneic BMT with ECP.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Bone Marrow Transplantation - adverse effects
- Cyclosporine - therapeutic use
- Extracorporeal Circulation -
- Female -
- Graft vs Host Disease - drug therapy Graft vs Host Disease - etiology
- Humans -
- Immunosuppressive Agents - therapeutic use
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy
- Lichen Planus -
- Male -
- Middle Aged -
- PUVA Therapy -
- Prednisolone - therapeutic use
- Remission Induction -
- Skin Diseases - drug therapy Skin Diseases - etiology
- Transplantation, Homologous - adverse effects
- Find related publications in this database (Keywords)
- immunomodulation
- ECP
- graft-versus-host disease
- GVHD photopheresis