Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kurz, M; Greinix, H; Höcker, P; Kalhs, P; Knöbl, P; Mayr, WR; Pober, M; Panzer, S.
Specificities of anti-platelet antibodies in multitransfused patients with haemato-oncological disorders.
Br J Haematol. 1996; 95(3):564-569
Doi: 10.1046/j.1365-2141.1996.d01-1936.x
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- The clinical condition and the formation of platelet-reactive antibodies influence the post-transfusion platelet increment. We analysed the specificities of platelet-reactive antibodies in 81 multitransfused patients with haemato-oncological diseases refractory to platelet transfusions, or prior to a scheduled stem cell transplantation. In 17 additional patients we prospectively determined the development of platelet-reactive antibodies at the time of chemotherapy in weekly intervals. Sera were tested by the monoclonal antibody-specific immobilization of platelet antigens (MAIPA)-technique for antiplatelet antibodies against HLA class I antigens, the human platelet-specific alloantigens (HPA)-1, -2, -3, -5, and the platelet membrane glycoproteins (GP) Ia/IIa, Ib/IX, IIb/IIIa (panreactive). Platelet reactive antibodies were found in 54% of blood samples. They were frequent in patients with a history of possible previous immunization, particularly if patients were refractory to platelet transfusions. Platelet-reactive HLA antibodies were the most common antibodies. Even patients without a known risk of primary immunization who received exclusively leucocyte-depleted blood products formed antibodies. By the MAIPA technique, even LCT-negative sera were found to contain platelet-reactive antibodies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Antibody Specificity -
- Blood Platelets - immunology
- Child -
- Child, Preschool -
- Hematologic Neoplasms - immunology Hematologic Neoplasms - therapy
- Humans -
- Infant -
- Middle Aged -
- Platelet Transfusion -
- Prospective Studies -
- Find related publications in this database (Keywords)
- platelet transfusion
- refractoriness
- immunization antiplatelet antibodies specificities