Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Keil, F; Kalhs, P; Haas, OA; Fritsch, G; Lechner, K; Mannhalter, C; Greinix, HT.
G-CSF stimulation of donor myelopoiesis prolongs survival of relapsed BCR-ABL-positive acute lymphoblastic leukemia after allogeneic marrow transplantation.
Bone Marrow Transplant. 1996; 18(3):655-657
(- Case Report)
Web of Science
PubMed
- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- An allogeneic sex-mismatched BMT which was performed in a male patient with BCR-ABL-positive ALL in second hematological and central nervous system relapse resulted in a CR for 12 months. After BMT, the patient was closely monitored with reverse transcription (RT)-PCR. One month before a third relapse RT-PCR became positive. During relapse G-CSF was administered. It specifically stimulated the donor-derived myelopoiesis and led to the stabilization of the disease for 8 months. Fluorescence in situ hybridization analyses of individual cell populations revealed that during the whole course of G-CSF administration granulocytes, CD4+, CD8+ and CD34+/CD10- cells were of female (donor) origin and only the CD34+/CD10+ cells which represented the leukemic blasts, were of male (host) origin.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Bone Marrow Transplantation -
- Female -
- Fusion Proteins, bcr-abl - analysis
- Granulocyte Colony-Stimulating Factor - pharmacology
- Hematopoiesis - drug effects
- Humans -
- Male -
- Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
- Transplantation, Homologous -
- Find related publications in this database (Keywords)
- relapse after allogeneic bone marrow transplantation
- BCR-ABL-positive acute lymphoblastic leukemia
- G-CSF stimulation of donor hematopoiesis