Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Becherer, A; Schulenburg, A; Bankl, HC; Schöfl, R; Keil, F; Reiter, E; Greinix, HT; Pikula, B; Kalhs, P.
Bile duct adenocarcinoma mimicking veno-occlusive disease after autologous bone marrow transplantation for acute leukaemia.
Bone Marrow Transplant. 1998; 21(12):1275-1277
Doi: 10.1038/sj.bmt.1701253
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- A 52-year-old female underwent autologous BMT because of acute myeloid leukaemia FAB M4 in second remission. Since the patient had no HLA-identical sibling she received a purged autologous BM transplant. On day +5 she developed signs of a sepsis syndrome with fluid retention and was treated with broad-spectrum antibiotic therapy. However, her body weight remained high, ascites and an increase of total serum bilirubin and alkaline phosphatase developed. The icterus worsened to a total bilirubin level of 25 mg/100 ml. Sonographic and endoscopic imaging showed a dilated gall bladder but disclosed a post-hepatic cause for the icterus. A transjugular liver biopsy on day +71 revealed severe cholestasis and siderosis. The patient remained aplastic with constantly increased bilirubin levels. On day +73 septic shock syndrome occurred and the patient died of multiorgan failure 3 days later. At autopsy, a highly differentiated bile duct adenocarcinoma at the porta hepatis, so-called Klatskin tumour, was found, explaining the fatal course with intractable cholestasis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - diagnosis
- Bile Duct Neoplasms - diagnosis
- Bone Marrow Transplantation - adverse effects
- Female -
- Hepatic Veno-Occlusive Disease - diagnosis
- Humans -
- Leukemia, Myeloid, Acute - therapy
- Middle Aged -
- Transplantation, Autologous -
- Find related publications in this database (Keywords)
- hepatic VOD
- cholestasis
- bile duct adenocarcinoma