Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Keil, F; Kalhs, P; Chen, X; Haas, OA; Fritsch, G; Chott, A; Lechner, K; Moser, K; Ackermann, J; Rabitsch, W; Worel, N; Mannhalter, C; Greinix, HT.
Hematopoietic donor chimerism and graft-versus-myeloma effect in relapse of multiple myeloma after allogeneic bone marrow transplantation.
Ann Hematol. 1999; 78(8):376-379
Doi: 10.1007/s002770050532
(- Case Report)
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- A large group of patients relapsing after allogeneic bone marrow transplantation (BMT) have obtained remission after infusion of leukocytes from their original donor, suggesting a graft-versus-myeloma effect. However, side effects such as graft-versus-host disease and myelosuppression are severe, and sometimes fatal, complications of this therapeutic approach. Previously we demonstrated that patients with leukemia who lack donor hematopoiesis in relapse after BMT experience severe and lasting aplasia after infusion of donor leukocytes. In two patients - one with extramedullary and one with marrow relapse after a sex-mismatched transplantation - we analyzed hematopoietic chimerism by cell sorting and bone marrow cultures. CD34-positive cells, CD4-CD8-positive cells, committed progenitors, and LTC-IC were of donor origin, as demonstrated by two-color fluorescence in situ hybridization (FISH). Additionally, in relapse complete donor T-cell chimerism was seen. In contrast, plasma cells were of recipient origin in the patient who had a relapse in the bone marrow. Both patients were treated with infusions of donor leukocytes from their original donor. Neither patient suffered myelosuppression, and one achieved a stable complete remission.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antigens, CD34 -
- Biopsy -
- Blood Donors -
- Bone Marrow - abnormalities Bone Marrow - pathology
- Bone Marrow Transplantation - immunology
- CD4-Positive T-Lymphocytes -
- CD8-Positive T-Lymphocytes - cytology
- Female -
- Graft vs Host Disease - therapy
- Graft vs Tumor Effect -
- Humans -
- In Situ Hybridization, Fluorescence -
- Leukapheresis -
- Male -
- Middle Aged -
- Multiple Myeloma - therapy
- Transplantation Chimera -
- Transplantation, Homologous -
- Find related publications in this database (Keywords)
- myeloma
- donor leukocyte infusion
- chimerism