Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Told, R; Schmidl, D; Palkovits, S; Boltz, A; Gouya, G; Wolzt, M; Witkowska, KJ; Popa-Cherecheanu, A; Werkmeister, RM; Garhöfer, G; Schmetterer, L.
Antioxidative capacity of a dietary supplement on retinal hemodynamic function in a human lipopolysaccharide (LPS) model.
Invest Ophthalmol Vis Sci. 2015; 56(1):403-411
Doi: 10.1167/iovs.14-15581
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Palkovits Stefan
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Beneficial effects of dietary supplements in age-related macular degeneration (AMD) are related to antioxidative properties. In the Age-Related Eye Disease Study 1 (AREDS 1), a reduced progression to late stage AMD was found using vitamin C, E, zinc, and β-carotene. We showed previously that the AREDS 1 formulation restores the O2-induced retinal vasoconstrictor response of retinal vessels in a human endotoxin (lipopolysaccharide [LPS]) model. We hypothesized that the abnormal O2-induced retinal red blood cell (RBC) flow response can be modulated by a different formulation (vitamin C, E, and zinc, lutein/zeaxanthin, selenium, taurine, Aronia extract, and omega-3 free fatty acids). A total of 43 healthy subjects was included in this randomized, double masked, placebo-controlled parallel group study. The reactivity of retinal arterial and venous diameter, RBC velocity, and flow to 100% O2 breathing was investigated in the absence and presence of 2 ng/kg LPS. Between the two study days was a 14-day period of daily dietary supplement intake. The decrease in retinal arterial diameter, RBC velocity, and flow during 100% O2 breathing was diminished significantly after LPS infusion. Dietary supplement intake for 14 days almost restored the response of retinal hemodynamic parameters to 100% O2 after LPS administration. This effect was significant for retinal arterial diameter (P = 0.03 between groups), and RBC velocity and flow (each P < 0.01 between groups). The present data indicate restoring of the RBC flow response to 100% O2 after LPS administration. This is likely due to an amelioration of endothelial dysfunction resulting from oxidative stress, a factor involved in AMD pathophysiology. (ClinicalTrials.gov number, NCT00914576.). Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Antioxidants - administration & dosage
- Dietary Supplements -
- Double-Blind Method -
- Female -
- Follow-Up Studies -
- Healthy Volunteers -
- Hemodynamics - drug effects
- Humans -
- Laser-Doppler Flowmetry -
- Lipopolysaccharides - adverse effects
- Macular Degeneration - chemically induced
- Male -
- Regional Blood Flow -
- Retina - drug effects
- Retinal Vessels - drug effects
- Treatment Outcome -
- Young Adult -
- Find related publications in this database (Keywords)
- retinal hemodynamic function
- retinal blood flow
- dietary supplements
- endotoxin model
- young healthy subjects
- red blood cell flow
- white blood cell flow