Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Palkovits, S; Told, R; Boltz, A; Schmidl, D; Popa Cherecheanu, A; Schmetterer, L; Garhöfer, G.
Effect of increased oxygen tension on flicker-induced vasodilatation in the human retina.
J Cereb Blood Flow Metab. 2014; 34(12): 1914-1918.
Doi: 10.1038/jcbfm.2014.161
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- Führende Autor*innen der Med Uni Graz
- Palkovits Stefan
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- Abstract:
- In the retina, blood flow and neural activity are tightly coupled. Stimulation of the retina with flickering light is accompanied by an increase in blood flow. The current study seeks to investigate whether an increase in oxygen tension modulates flicker (FL)-induced vasodilatation in the human retina. A total of 52 healthy volunteers were included. Via a breathing mask, 100% oxygen (O(2)) was administered in one, a mixture of 8% carbon dioxide and 92% oxygen (C/O) in a second cohort. Retinal vessel diameters were measured with a Vessel Analyzer and FL responses were assessed before and during the breathing periods. At baseline, FL stimulation increased retinal vessel diameters by +3.7±2.3% in arteries and by +5.1±3.7% in veins. Breathing of C/O led to a decrease in arterial (-9.0±6.9%) and venous (-11.3±5.9%) vessel calibers. Flicker response was increased to 5.7±2.5% in arteries and to 8.6±4.1% in veins. Breathing of pure O2 induced a vasoconstriction of vessel diameters by -14.0±5.3% in arteries and -18.4±7.0% in veins and increased FL responses in arteries (+6.2±2.8%) and veins (+7.2±3.1%). Systemic hyperoxia increases FL-induced retinal vasodilatation in the retina. The mechanism by which oxygen modulates the hyperemic response to FL stimulation remains to be elucidated.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Carbon Dioxide - administration & dosage Carbon Dioxide - blood
- Female -
- Humans -
- Hyperoxia - physiopathology
- Laser-Doppler Flowmetry -
- Male -
- Oximetry -
- Oxygen - administration & dosage Oxygen - blood
- Partial Pressure -
- Photic Stimulation -
- Regional Blood Flow - physiology
- Retina - metabolism
- Retinal Artery - physiology
- Retinal Vein - physiology
- Vasodilation - physiology
- Young Adult -
- Find related publications in this database (Keywords)
- hemodynamics
- neurovascular coupling
- physiology