Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Maier, K; Rau, CR; Storch, MK; Sättler, MB; Demmer, I; Weissert, R; Taheri, N; Kuhnert, AV; Bähr, M; Diem, R.
Ciliary neurotrophic factor protects retinal ganglion cells from secondary cell death during acute autoimmune optic neuritis in rats.
Brain Pathol. 2004; 14(4):378-387
Doi: 10.1111/j.1750-3639.2004.tb00081.x
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- Co-authors Med Uni Graz
- Storch Maria
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- Abstract:
- Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS which leads to demyelination, axonal destruction and neuronal loss in the early stages. Available therapies mainly target the inflammatory component of the disease but fail to prevent neurodegeneration. To investigate the effect of ciliary neurotrophic factor (CNTF) on the survival of retinal ganglion cells (RGCs), the neurons that form the axons of the optic nerve, we used a rat model of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. Optic neuritis in this model was diagnosed by recording visual evoked potentials, and RGC function was monitored by measuring electroretinograms. This study demonstrates that CNTF has a neuroprotective effect on affected RGCs during acute optic neuritis. Furthermore, we demonstrate that CNTF exerts its neuroprotective effect through activation of the Janus kinase/signal transducer and activator of transcription pathway, mitogen activated protein kinases and a shift in the Bcl-2 family of proteins towards the anti-apoptotic side. In summary, our results demonstrate that CNTF can serve as an effective neuroprotective treatment in a rat model of MS that especially reflects the neurodegenerative aspects of this disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Analysis of Variance -
- Animals -
- Blotting, Western - methods
- Cell Count - methods
- Cell Death - drug effects
- Ciliary Neurotrophic Factor - therapeutic use
- DNA-Binding Proteins - metabolism
- Drug Combinations - metabolism
- Enzyme Inhibitors - administration and dosage
- Evoked Potentials, Visual - drug effects
- Female - drug effects
- Flavonoids - administration and dosage
- Fluorescent Dyes - diagnostic use
- Gene Expression Regulation - drug effects
- Mitogen-Activated Protein Kinase Kinases - antagonists and inhibitors
- Nerve Degeneration - etiology
- Optic Nerve - drug effects
- Optic Neuritis - pathology
- Photic Stimulation - methods
- Proto-Oncogene Proteins c-bcl-2 - metabolism
- Rats - metabolism
- Retinal Ganglion Cells - drug effects
- STAT3 Transcription Factor - drug effects
- Stilbamidines - diagnostic use
- Time Factors - diagnostic use
- Trans-Activators - metabolism
- Visual Cortex - drug effects
- bcl-2-Associated X Protein - drug effects