Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Folci, A; Mapelli, L; Sassone, J; Prestori, F; D'Angelo, E; Bassani, S; Passafaro, M.
Loss of hnRNP K impairs synaptic plasticity in hippocampal neurons.
J Neurosci. 2014; 34(27): 9088-9095.
Doi: 10.1523/JNEUROSCI.0303-14.2014
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Folci Alessandra Chiara
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an RNA-binding protein implicated in RNA metabolism. Here, we investigated the role of hnRNP K in synapse function. We demonstrated that hnRNP K regulates dendritic spine density and long-term potentiation (LTP) in cultured hippocampal neurons from embryonic rats. LTP requires the extracellular signal-regulated kinase (ERK)1/2-mediated phosphorylation and cytoplasmic accumulation of hnRNP K. Moreover, hnRNP K knockdown prevents ERK cascade activation and GluA1-S845 phosphorylation and surface delivery, which are essential steps for LTP. These findings establish hnRNP K as a new critical regulator of synaptic transmission and plasticity in hippocampal neurons. Copyright © 2014 the authors 0270-6474/14/349088-08$15.00/0.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcium Signaling -
- Cells, Cultured -
- Dendrites - ultrastructure
- Female -
- Gene Expression Regulation - drug effects Gene Expression Regulation - physiology
- Hippocampus - cytology
- Long-Term Potentiation - physiology
- MAP Kinase Signaling System -
- Male -
- Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology
- Neurons - physiology Neurons - ultrastructure
- Phosphorylation -
- Protein Processing, Post-Translational -
- Protein Transport -
- RNA Interference -
- RNA, Small Interfering - pharmacology
- Rats -
- Receptors, AMPA - metabolism
- Ribonucleoproteins - antagonists & inhibitors Ribonucleoproteins - genetics Ribonucleoproteins - physiology
- Synaptic Transmission - physiology
- Transfection -
- Find related publications in this database (Keywords)
- dendritic spines
- hnRNP K
- LTP
- neurons
- synapse