Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bassani, S; Folci, A; Zapata, J; Passafaro, M.
AMPAR trafficking in synapse maturation and plasticity.
Cell Mol Life Sci. 2013; 70(23): 4411-4430.
Doi: 10.1007/s00018-013-1309-1
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Folci Alessandra Chiara
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Glutamate ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors (AMPARs) mediate most fast excitatory synaptic transmission in the central nervous system. The content and composition of AMPARs in postsynaptic membranes (which determine synaptic strength) are dependent on the regulated trafficking of AMPAR subunits in and out of the membranes. AMPAR trafficking is a key mechanism that drives nascent synapse development, and is the main determinant of both Hebbian and homeostatic plasticity in mature synapses. Hebbian plasticity seems to be the biological substrate of at least some forms of learning and memory; while homeostatic plasticity (also known as synaptic scaling) keeps neuronal circuits stable by maintaining changes within a physiological range. In this review, we examine recent findings that provide further understanding of the role of AMPAR trafficking in synapse maturation, Hebbian plasticity, and homeostatic plasticity.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Homeostasis - physiology
- Humans -
- Models, Neurological -
- Neuronal Plasticity - physiology
- Protein Transport - physiology
- Receptors, AMPA - metabolism Receptors, AMPA - physiology
- Synapses - metabolism Synapses - physiology
- Synaptic Transmission - physiology
- Find related publications in this database (Keywords)
- AMPAR trafficking
- Synaptic plasticity
- Synapse maturation