Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Miñarro-Giménez, JA; Blagec, K; Boyce, RD; Adlassnig, KP; Samwald, M.
An ontology-based, mobile-optimized system for pharmacogenomic decision support at the point-of-care.
PLoS One. 2014; 9(5):e93769-e93769 Doi: 10.1371/journal.pone.0093769 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Leading authors Med Uni Graz: Minarro-Gimenez Jose Antonio
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: The development of genotyping and genetic sequencing techniques and their evolution towards low costs and quick turnaround have encouraged a wide range of applications. One of the most promising applications is pharmacogenomics, where genetic profiles are used to predict the most suitable drugs and drug dosages for the individual patient. This approach aims to ensure appropriate medical treatment and avoid, or properly manage, undesired side effects. We developed the Medicine Safety Code (MSC) service, a novel pharmacogenomics decision support system, to provide physicians and patients with the ability to represent pharmacogenomic data in computable form and to provide pharmacogenomic guidance at the point-of-care. Pharmacogenomic data of individual patients are encoded as Quick Response (QR) codes and can be decoded and interpreted with common mobile devices without requiring a centralized repository for storing genetic patient data. In this paper, we present the first fully functional release of this system and describe its architecture, which utilizes Web Ontology Language 2 (OWL 2) ontologies to formalize pharmacogenomic knowledge and to provide clinical decision support functionalities. The MSC system provides a novel approach for enabling the implementation of personalized medicine in clinical routine.
Find related publications in this database (using NLM MeSH Indexing): Biological Ontologies -; Cell Phone -; Decision Support Techniques -; Genotype -; Humans -; Medication Errors - prevention & control; Pharmacogenetics - methods; Point-of-Care Systems -