Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Richtig, E; Trapp, EM; Avian, A; Brezinsek, HP; Trapp, M; Egger, JW; Kapfhammer, HP; Rohrer, PM; Berghold, A; Curiel-Lewandrowski, C; Demel, U.
Psychological Stress and Immunological Modulations in Early-stage Melanoma Patients.
Acta Derm Venereol. 2015; 95(6):691-695
Doi: 10.2340/00015555-2045
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- Führende Autor*innen der Med Uni Graz
- Richtig Erika
- Co-Autor*innen der Med Uni Graz
- Avian Alexander
- Berghold Andrea
- Brezinsek Hans-Peter
- Demel Ulrike
- Egger Josef Wilhelm
- Kapfhammer Hans-Peter
- Rohrer Peter Michael
- Trapp Eva-Maria
- Trapp Michael
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- Abstract:
- Mental stress may have a negative impact on the immune state of cancer patients, in whom immunologic surveillance is essential for survival. This study investigated the immunological response of 19 patients with early-stage melanoma and a matched control group undergoing the Determination Stress Test before surgery. Cytokine and chemokine levels and lymphocyte subpopulations were measured at baseline and post-stress test time-points. Following the stress test lower levels of interleukin (IL)-6 were observed in the melanoma group compared with healthy volunteers (p = 0.044). IL-10 increased significantly in the control group 30 min after the stress test (p = 0.002) in comparison with the melanoma group (p = 0.407). CCL5/Rantes decreased significantly in the melanoma group, whereas CD16/CD56+ natural killer cells increased in both groups, with a sharp decrease below baseline after stress in the melanoma group (p = 0.001). This pilot study shows an altered immunological response to stressors in melanoma patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- CD4 Lymphocyte Count -
- CD8-Positive T-Lymphocytes -
- Case-Control Studies -
- Chemokine CCL5 - blood
- Chemokines - blood
- Female -
- Humans -
- Interleukin-10 - blood
- Interleukin-6 - blood
- Killer Cells, Natural -
- Male -
- Melanoma - blood
- Melanoma - immunology
- Melanoma - psychology
- Melanoma - surgery
- Middle Aged -
- Pilot Projects -
- Skin Neoplasms - blood
- Skin Neoplasms - immunology
- Skin Neoplasms - psychology
- Skin Neoplasms - surgery
- Stress, Psychological - blood
- Stress, Psychological - etiology
- Stress, Psychological - immunology
- Find related publications in this database (Keywords)
- melanoma
- cytokines
- chemokines
- lymphocytes
- stress