Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Pierce, DM; Maier, F; Weisbecker, H; Viertler, C; Verbrugghe, P; Famaey, N; Fourneau, I; Herijgers, P; Holzapfel, GA.
Human thoracic and abdominal aortic aneurysmal tissues: Damage experiments, statistical analysis and constitutive modeling.
J Mech Behav Biomed Mater. 2015; 41(1):92-107
Doi: 10.1016/j.jmbbm.2014.10.003
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Viertler Christian
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Development of aortic aneurysms includes significant morphological changes within the tissue: collagen content increases, elastin content reduces and smooth muscle cells degenerate. We seek to quantify the impact of these changes on the passive mechanical response of aneurysms in the supra-physiological loading range via mechanical testing and constitutive modeling. We perform uniaxial extension tests on circumferentially and axially oriented strips from five thoracic (65.6 years ± 13.4, mean ± SD) and eight abdominal (63.9 years ± 11.4) aortic fusiform aneurysms to investigate both continuous and discontinuous softening during supra-physiological loading. We determine the significance of the differences between the fitted model parameters: diseased thoracic versus abdominal tissues, and healthy (Weisbecker et al., J. Mech. Behav. Biomed. Mater. 12, 93-106, 2012) versus diseased tissues. We also test correlations among these parameters and age, Body Mass Index (BMI) and preoperative aneurysm diameter, and investigate histological cuts. Tissue response is anisotropic for all tests and the anisotropic pseudo-elastic damage model fits the data well for both primary loading and discontinuous softening which we interpret as damage. We found statistically relevant differences between model parameters fitted to diseased thoracic versus abdominal tissues, as well as between those fitted to healthy versus diseased tissues. Only BMI correlated with fitted model parameters in abdominal aortic aneurysmal tissues. Copyright © 2014 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Age Factors -
- Aged -
- Aortic Aneurysm, Abdominal - pathology
- Aortic Aneurysm, Abdominal - physiopathology
- Aortic Aneurysm, Thoracic - pathology
- Aortic Aneurysm, Thoracic - physiopathology
- Body Mass Index -
- Female -
- Humans -
- Male -
- Middle Aged -
- Models, Biological -
- Statistics as Topic -
- Find related publications in this database (Keywords)
- Human aorta
- Aortic aneurysm
- Supra-physiological loading
- Constitutive modeling
- Damage modeling