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SHR Neuro Cancer Cardio Lipid Metab Microb
Pfleger, A; Steinbacher, M; Schwantzer, G; Weinhandl, E; Wagner, M; Eber, E.
Short-term effects of physiotherapy on ventilation inhomogeneity in cystic fibrosis patients with a wide range of lung disease severity.
J Cyst Fibros. 2015; 14(5):627-631
Doi: 10.1016/j.jcf.2014.12.017
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- Leading authors Med Uni Graz
- Eber Ernst
- Pfleger Andreas
- Co-authors Med Uni Graz
- Schwantzer Gerold
- Steinbacher Michael
- Wagner Marlies
- Weinhandl Elisabeth
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- Abstract:
- Lung clearance index (LCI) is increasingly used as a study endpoint for therapeutic interventions in cystic fibrosis (CF) patients. We set out to assess the effect of chest physiotherapy on ventilation inhomogeneity in clinically stable patients with CF lung disease of varying severity. In 29 CF patients (7.3-43.7 years) N2MBW (nitrogen multiple breath washout), plethysmography, and spirometry measurements were conducted, followed by 30 min of supervised PEP mask chest physiotherapy and repeated measurements 30 min after therapy. We observed a mean change in LCI after physiotherapy from 15.00 to 14.80 (range, -4.84 to 3.37; p=0.578). In seven patients, LCI decreased, and in ten patients, LCI increased by ≥1. For the whole group, statistically significant improvements were seen in Reff, FEV1, FVC, and MEF50. By opening up previously poorly ventilated lung regions, physiotherapy may either increase or decrease ventilation inhomogeneity; the short-term effect of physiotherapy on LCI appears to be unpredictable. Copyright © 2015 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Child -
- Child, Preschool -
- Cystic Fibrosis - diagnosis
- Cystic Fibrosis - physiopathology
- Cystic Fibrosis - rehabilitation
- Female -
- Follow-Up Studies -
- Forced Expiratory Volume - physiology
- Humans -
- Lung - physiopathology
- Male -
- Physical Therapy Modalities -
- Plethysmography -
- Prognosis -
- Prospective Studies -
- Severity of Illness Index -
- Spirometry -
- Young Adult -
- Find related publications in this database (Keywords)
- Airway clearance
- Cystic fibrosis
- Lung function test
- Multiple breath washout
- Physiotherapy
- Spirometry