Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Szkandera, J; Gerger, A; Liegl-Atzwanger, B; Stotz, M; Samonigg, H; Friesenbichler, J; Stojakovic, T; Leithner, A; Pichler, M.
The derived neutrophil/lymphocyte ratio predicts poor clinical outcome in soft tissue sarcoma patients.
Am J Surg. 2015; 210(1): 111-116.
Doi: 10.1016/j.amjsurg.2014.10.021
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Szkandera Joanna
- Co-Autor*innen der Med Uni Graz
- Friesenbichler Jörg
- Gerger Armin
- Leithner Andreas
- Liegl-Atzwanger Bernadette
- Pichler Martin
- Samonigg Hellmut
- Stojakovic Tatjana
- Stotz Michael
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- Abstract:
- Inflammation plays an important role in tumor proliferation and survival in cancer patients. The aim of this study was to investigate the prognostic impact of the pre-operative-derived neutrophil/lymphocyte ratio (dNLR) in a large cohort of soft tissue sarcoma (STS) patients after curative surgical resection. The impact of preoperative dNLR on disease-free survival (DFS) and overall survival (OS) in retrospectively evaluated 340 STS patients was assessed using Kaplan-Meier curves and Cox proportional models. Applying receiver operating curve analysis, we determined a cut-off value of 2.39 for the dNLR to be optimal for discrimination of patients' survival in the whole cohort. Kaplan-Meier curves revealed a dNLR greater than or equal to 2.39 as a marker for decreased DFS (P = .031) and OS (P = .007, log-rank test) in STS patients. In multivariate analysis, increased dNLR was significantly associated with poor OS (hazard ratio 1.60, 95% confidence interval 1.07 to 2.40, P = .022). This study demonstrates that preoperative dNLR might represent a well-correlated surrogate marker for the widely validated NLR. The dNLR is easily obtainable and can provide important information for individual risk assessment in clinical trials. Copyright © 2015 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Disease-Free Survival -
- Female -
- Humans -
- Leukocyte Count -
- Lymphocytes -
- Male -
- Middle Aged -
- Neutrophils -
- Predictive Value of Tests -
- Retrospective Studies -
- Sarcoma - blood Sarcoma - surgery
- Soft Tissue Neoplasms - blood Soft Tissue Neoplasms - surgery
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Derived neutrophil/lymphocyte ratio
- Soft tissue sarcoma
- Prognostic marker
- Inflammation