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SHR Neuro Cancer Cardio Lipid Metab Microb

Madl, T; Felli, IC; Bertini, I; Sattler, M.
Structural analysis of protein interfaces from 13C direct-detected paramagnetic relaxation enhancements.
J Am Chem Soc. 2010; 132(21): 7285-7287. Doi: 10.1021/ja1014508
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Leading authors Med Uni Graz
Madl Tobias
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Abstract:
The measurement of (13)C directed-detected paramagnetic relaxation enhancements (PREs) on spin-labeled proteins combines the efficacy of PREs for the detection of long-range distance information with the favorable sensitivity and resolution of (13)C direct-detected experiments. The (13)C PREs provide long-range distance restraints to map binding interfaces in proteins and protein complexes and are especially useful for studies of high-molecular weight perdeuterated molecules.
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