Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lussier, YA; Xing, HR; Salama, JK; Khodarev, NN; Huang, Y; Zhang, Q; Khan, SA; Yang, X; Hasselle, MD; Darga, TE; Malik, R; Fan, H; Perakis, S; Filippo, M; Corbin, K; Lee, Y; Posner, MC; Chmura, SJ; Hellman, S; Weichselbaum, RR.
MicroRNA expression characterizes oligometastasis(es).
PLoS One. 2011; 6(12): e28650-e28650.
Doi: 10.1371/journal.pone.0028650
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Hasenleithner Samantha
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Cancer staging and treatment presumes a division into localized or metastatic disease. We proposed an intermediate state defined by ≤ 5 cumulative metastasis(es), termed oligometastases. In contrast to widespread polymetastases, oligometastatic patients may benefit from metastasis-directed local treatments. However, many patients who initially present with oligometastases progress to polymetastases. Predictors of progression could improve patient selection for metastasis-directed therapy. Here, we identified patterns of microRNA expression of tumor samples from oligometastatic patients treated with high-dose radiotherapy. Patients who failed to develop polymetastases are characterized by unique prioritized features of a microRNA classifier that includes the microRNA-200 family. We created an oligometastatic-polymetastatic xenograft model in which the patient-derived microRNAs discriminated between the two metastatic outcomes. MicroRNA-200c enhancement in an oligometastatic cell line resulted in polymetastatic progression. These results demonstrate a biological basis for oligometastases and a potential for using microRNA expression to identify patients most likely to remain oligometastatic after metastasis-directed treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Line, Tumor -
- Cluster Analysis -
- Databases, Genetic -
- Disease Models, Animal -
- Disease Progression -
- Female -
- Gene Expression Profiling -
- Gene Expression Regulation, Neoplastic -
- Humans -
- Lung - pathology
- Mice -
- MicroRNAs - genetics MicroRNAs - metabolism
- Neoplasm Metastasis - genetics
- Reproducibility of Results -
- Xenograft Model Antitumor Assays -