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Cancer
Cardio
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Metab
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Massone, C; Cerroni, L.
The many clinico-pathologic faces of actinic keratosis: an atlas.
Curr Probl Dermatol. 2015; 46(6):64-69
Doi: 10.1159/000366538
PubMed
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- Leading authors Med Uni Graz
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Massone Cesare
- Co-authors Med Uni Graz
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Cerroni Lorenzo
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- Abstract:
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Actinic keratoses (AKs) are intraepithelial neoplasms formed by atypical keratinocyte proliferation. Histopathologically, typical AKs are characterized by a slightly thickened epidermis, usually with irregular downward buds, orthokeratosis alternating with parakeratosis ('pink and blue') with loss of the underlying granular layer and a disarrangement of the epidermis with atypical keratinocytes at the basal layer. There are several histopathological variants of AK according to the different degrees of keratinocytic atypia, epidermal hyperplasia/atrophy, inflammation and pigmentation. Some authors consider AK an early in situ squamous cell carcinoma and propose a classification of AK based on the extent of atypical keratinocytes in the epidermis.
© 2015 S. Karger AG, Basel.
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