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SHR Neuro Cancer Cardio Lipid Metab Microb

Winding, L; Loane, M; Wellesley, D; Addor, MC; Arriola, L; Bakker, MK; Bianchi, F; Calzolari, E; Gatt, M; Haeusler, M; Lelong, N; Mullaney, C; Scarano, G; Tucker, D; Wiesel, A; Garne, E.
Prenatal diagnosis and epidemiology of multicystic kidney dysplasia in Europe.
Prenat Diagn. 2014; 34(11):1093-1098 Doi: 10.1002/pd.4433
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Haeusler Martin
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Abstract:: The aim of this study is to describe the prenatal diagnosis and epidemiology of multicystic kidney dysplasia (MCKD). The study is based on routinely collected data from a European database of major congenital anomalies including 13 registries with cases born in 1997-2006 and covering 1 458 552 births. There were 601 MCKD cases giving an overall prevalence of 4.12 per 10 000 births with regional variation. In live births, 87% of cases had an isolated renal anomaly and 13% had associated major nonrenal anomalies (chromosomal, syndrome or other major anomalies). For the cases with isolated renal anomalies, 51/386 (11%) and 7/386 (2%) choose to terminate the pregnancy or resulted in an intrauterine fetal death, respectively. The prenatal detection rate was 88% in both unilateral and bilateral cases. Birth outcome differed with 92% of unilateral MCKD cases being liveborn compared with 33% of bilateral MCKD cases. For unilateral MCKD cases, 84% had an isolated renal anomaly compared with 51% of bilateral MCKD cases (p < 0.001). Cases with unilateral MCKD are mainly liveborn, and only 16% have associated major malformations or a syndrome. Cases with bilateral MCKD are often associated with nonrenal major congenital anomalies or part of a syndrome, and only one third of bilateral MCKD cases in this study were liveborn. Prenatal detection rate of MCKD was high for both unilateral and bilateral cases. © 2014 John Wiley & Sons, Ltd. © 2014 John Wiley & Sons, Ltd.
Find related publications in this database (using NLM MeSH Indexing): Abnormalities, Multiple - epidemiology; Abnormalities, Multiple - epidemiology; Female -; Fetal Death -; Gestational Age -; Humans -; Infant, Newborn -; Live Birth - epidemiology; Male -; Multicystic Dysplastic Kidney - diagnosis; Multicystic Dysplastic Kidney - epidemiology; Pregnancy -; Prenatal Diagnosis - statistics & numerical data; Prevalence -; Registries - statistics & numerical data; Stillbirth - epidemiology