Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Liu, X; Kunert, O; Blunder, M; Fakhrudin, N; Noha, SM; Malainer, C; Schinkovitz, A; Heiss, EH; Atanasov, AG; Kollroser, M; Schuster, D; Dirsch, VM; Bauer, R.
Polyyne hybrid compounds from Notopterygium incisum with peroxisome proliferator-activated receptor gamma agonistic effects.
J Nat Prod. 2014; 77(11):2513-2521
Doi: 10.1021/np500605v
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- Co-Autor*innen der Med Uni Graz
- Kollroser Manfred
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- Abstract:
- In the search for peroxisome proliferator-activated receptor gamma (PPARγ) active constituents from the roots and rhizomes of Notopterygium incisum, 11 new polyacetylene derivatives (1-11) were isolated. Their structures were elucidated by NMR and HRESIMS as new polyyne hybrid molecules of falcarindiol with sesquiterpenoid or phenylpropanoid moieties, named notoethers A-H (1-8) and notoincisols A-C (9-11), respectively. Notoincisol B (10) and notoincisol C (11) represent two new carbon skeletons. When tested for PPARγ activation in a luciferase reporter assay with HEK-293 cells, notoethers A-C (1-3), notoincisol A (9), and notoincisol B (10) showed promising agonistic activity (EC50 values of 1.7 to 2.3 μM). In addition, notoincisol A (9) exhibited inhibitory activity on NO production of stimulated RAW 264.7 macrophages.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Apiaceae - chemistry
- Diynes - pharmacology
- Fatty Alcohols - pharmacology
- HEK293 Cells -
- Humans -
- Lipopolysaccharides - pharmacology
- Luciferases - metabolism
- Macrophages - drug effects
- Mice -
- Molecular Structure -
- Nitric Oxide - biosynthesis
- PPAR gamma - drug effects
- Plant Roots - chemistry
- Polyynes - chemistry
- Polyynes - isolation & purification
- Polyynes - pharmacology
- Rhizome - chemistry