Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Nacht, B; Larndorfer, C; Sax, S; Borisov, SM; Hajnsek, M; Sinner, F; List-Kratochvil, EJ; Klimant, I.
Integrated catheter system for continuous glucose measurement and simultaneous insulin infusion.
Biosens Bioelectron. 2015; 64(2):102-110
Doi: 10.1016/j.bios.2014.08.012
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Sinner Frank Michael
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- Abstract:
- A new measurement system enables combination of continuous glucose monitoring (CGM) and insulin infusion. A sensor system comprising an optical glucose biosensor and an optical oxygen sensor is integrated into the insulin infusion catheter of an insulin pump. Both sensors rely on near infrared (NIR) phosphorescent porphyrin dyes, wherefore the signals can be read out transcutaneous and non-invasively with a custom-built phase fluorometer measurement module. The spectral properties of the indicator dyes and the optical setup of the measurement module were optimized to enable independent read-out in two channels. Dynamic ranges from 0 mmHg to 160 mmHg oxygen and 0mg/dL to 360 mg/dL glucose (LOD 2mg/dL) are covered by the oxygen and the glucose sensor, respectively. In-vivo measurements in pigs demonstrate good correlation of reference blood glucose levels and glucose values obtained with the presented sensor system. The evaluation of the clinical accuracy of the system with Clarke Error Grid Analysis showed similar results to CGM-devices currently on the market. Copyright © 2014 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Cutaneous -
- Animals -
- Biosensing Techniques - instrumentation
- Blood Glucose - analysis
- Blood Glucose Self-Monitoring - instrumentation
- Catheters -
- Cell Line -
- Equipment Design -
- Humans -
- Insulin - administration & dosage
- Insulin Infusion Systems -
- Swine -
- Find related publications in this database (Keywords)
- Continuous glucose monitoring
- CGM
- Optical sensor
- Porphyrin
- Insulin infusion
- Implantable glucose sensor