Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cvitic, S; Desoye, G; Hiden, U.
Glucose, insulin, and oxygen interplay in placental hypervascularisation in diabetes mellitus.
Biomed Res Int. 2014; 2014(16):145846-145846
Doi: 10.1155/2014/145846
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- Führende Autor*innen der Med Uni Graz
- Tokic Silvija
- Co-Autor*innen der Med Uni Graz
- Desoye Gernot
- Hiden Ursula
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- Abstract:
- The placental vasculature rapidly expands during the course of pregnancy in order to sustain the growing needs of the fetus. Angiogenesis and vascular growth are stimulated and regulated by a variety of growth factors expressed in the placenta or present in the fetal circulation. Like in tumors, hypoxia is a major regulator of angiogenesis because of its ability to stimulate expression of various proangiogenic factors. Chronic fetal hypoxia is often found in pregnancies complicated by maternal diabetes as a result of fetal hyperglycaemia and hyperinsulinemia. Both are associated with altered levels of hormones, growth factors, and proinflammatory cytokines, which may act in a proangiogenic manner and, hence, affect placental angiogenesis and vascular development. Indeed, the placenta in diabetes is characterized by hypervascularisation, demonstrating high placental plasticity in response to diabetic metabolic derangements. This review describes the major regulators of placental angiogenesis and how the diabetic environment in utero alters their expression. In the light of hypervascularized diabetic placenta, the focus was placed on proangiogenic factors.
- Find related publications in this database (using NLM MeSH Indexing)
- Diabetes, Gestational - metabolism
- Female -
- Glucose - metabolism
- Humans -
- Insulin - metabolism
- Neovascularization, Physiologic -
- Oxygen - metabolism
- Placenta - blood supply
- Pregnancy -