Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fuchs, R; Schwach, G; Stracke, A; Meier-Allard, N; Absenger, M; Ingolic, E; Haas, HS; Pfragner, R; Sadjak, A.
The anti-hypertensive drug prazosin induces apoptosis in the medullary thyroid carcinoma cell line TT.
Anticancer Res. 2015; 35(1):31-38
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- Führende Autor*innen der Med Uni Graz
- Fuchs Robert
- Schwach Gert
- Co-Autor*innen der Med Uni Graz
- Absenger-Novak Markus
- Haas Helga Susanne
- Meier-Allard Nathalie
- Pfragner Roswitha
- Sadjak Anton
- Stracke Anika
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- Abstract:
- Medullary thyroid carcinoma (MTC) is a tumor associated with poor prognosis since it exhibits high resistance against conventional cancer therapy. Recent studies have shown that quinazolines exhibit a pro-apoptotic effect on malignant cells. The aim of the present study was to elucidate whether MTC cells are affected by quinazolines, in particular prazosin. Proliferation, apoptosis and cell morphology of the MTC cell line TT were analyzed by WST-1 assay, caspase 3/7 activation tests and microscopy. Fibroblasts were used as control for non-malignant cells. Prazosin potently inhibited the growth of TT cells, induced apoptosis and caused vacuolization, as well as needle-like filopodia. Fibroblasts were affected by prazosin in the same way as MTC cells. MTC cells are responsive to prazosin treatment similar to other malignancies. The fact that fibroblasts also respond to prazosin further highlights the importance to identify the unknown pro-apoptotic target of quinazolines. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Antihypertensive Agents - pharmacology
- Antineoplastic Agents - pharmacology
- Apoptosis - drug effects
- Carcinoma, Medullary - drug therapy
- Cell Line, Tumor - drug effects
- Drug Screening Assays, Antitumor -
- Humans -
- Prazosin - pharmacology
- Receptors, Adrenergic, alpha-1 - metabolism
- Thyroid Neoplasms - drug therapy
- Find related publications in this database (Keywords)
- Medullary thyroid carcinoma
- cell culture
- alpha 1-adrenergic receptors
- quinazolines
- prazosin
- apoptosis