Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Langner, C.
Serrated and non-serrated precursor lesions of colorectal cancer.
Dig Dis. 2015; 33(1):28-37
Doi: 10.1159/000366032
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Langner Cord
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- Abstract:
- Although often viewed as a single disease, colorectal cancer more accurately represents a family of diseases with different precursor lesions. Conventional (tubular, tubulovillous and villous) adenomas are the most common neoplastic lesions occurring in the large intestine. They have adenomatous polyposis coli (APC) mutations and arise from dysplastic aberrant crypt foci, initially as polyclonal lesions. In sporadic tumours, neoplastic progression follows the traditional pathway (chromosomal instability pathway), resulting in CpG island methylator phenotype (CIMP)-negative, microsatellite-stable (MSS), BRAF and KRAS wild-type cancers. Germline mutations in the APC gene lead to familial adenomatous polyposis. Conventional adenomas are also the precursors of Lynch syndrome-associated microsatellite-instable (MSI-high) cancers. Sessile serrated adenoma/polyp (SSA/P) is the principal precursor lesion of the serrated pathway, in which BRAF mutation can lead to colorectal cancer with MSI-high CIMP-high or MSS CIMP-high phenotype. SSA/Ps have been associated with synchronous and metachronous invasive adenocarcinomas as well as so-called interval carcinomas. Serrated polyposis is rare but most likely underdiagnosed. Affected individuals bear an increased but unspecified risk for the development of colorectal cancer; close endoscopic surveillance is warranted. Traditional serrated adenomas (TSAs) are much less common than the other serrated lesions. Cancers originating from TSAs may show KRAS mutation with a CIMP-high MSS phenotype. © 2014 S. Karger AG, Basel.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenoma - epidemiology
- Adenoma - pathology
- Colorectal Neoplasms - pathology
- Disease Progression -
- Humans -
- Hyperplasia -
- Intestinal Polyps - pathology
- Precancerous Conditions - pathology
- Find related publications in this database (Keywords)
- Colon
- Rectum
- Tubular adenoma
- Tubulovillous adenoma
- Villous adenoma
- Sessile serrated adenoma
- Traditional serrated adenoma
- Histology
- Molecular pathology
- Adenocarcinoma