Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wackernagel, A; Bergmann, AR; Aberer, E.
Acute exacerbation of systemic scleroderma in Borrelia burgdorferi infection.
J EUR ACAD DERMATOL VENEREOL. 2005; 19(1): 93-96.
Doi: 10.1111/j.1468-3083.2004.01074.x
(- Case Report)
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Aberer Elisabeth
- Gruber-Wackernagel Alexandra
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- Abstract:
- In recent years a possible aetiological connection between skin sclerosis and an infection with Borrelia burgdorferi has been discussed, but this association has not yet been reported for systemic scleroderma. Several treatment modalities are suggested for systemic scleroderma, but no treatment has yet been found to alter the overall course of the disease. This report describes a 61-year-old woman with Raynaud's phenomenon, nail-fold changes and circulating anticentromere antibodies, who showed an abrupt onset of erythemas and doughy swellings involving the face and upper trunk, followed by thickening and induration of the skin mimicking diffuse systemic scleroderma. Laboratory tests including enzyme-linked immunosorbent assay (ELISA), immunoblot and urine polymerase chain reaction (PCR) showed an infection with B. burgdorferi sensu lato that was successfully treated with intravenous ceftriaxone, an antibiotic recommended for Lyme borreliosis. Fourteen days after the end of treatment the skin was no longer stiff and indurated and had returned to its normal predisease state. This case suggests that Lyme disease should be considered in atypical cases of skin sclerosis in patients predisposed to the development of systemic scleroderma.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Anti-Bacterial Agents - therapeutic use
- Ceftriaxone - therapeutic use
- Diagnosis, Differential -
- Female -
- Humans -
- Lyme Disease - complications Lyme Disease - diagnosis Lyme Disease - drug therapy
- Middle Aged -
- Scleroderma, Systemic - complications Scleroderma, Systemic - diagnosis
- Find related publications in this database (Keywords)
- B. burgdorferi
- ceftriaxone
- systemic scleroderma
- urine PCR