Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schwach, G; Thamyongkit, P; Reith, LM; Svejda, B; Knör, G; Pfragner, R; Schoefberger, W.
A water soluble tri-cationic porphyrin-EDTA conjugate induces apoptosis in human neuroendocrine tumor cell lines.
Bioorg Chem. 2012; 40(1): 108-113.
Doi: 10.1016/j.bioorg.2011.09.006
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- Leading authors Med Uni Graz
- Pfragner Roswitha
- Schwach Gert
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- Abstract:
- In this study, a completely water soluble tri-cationic porphyrin-EDTA conjugate was synthesized. We present data demonstrating the tumoristatic effects of the novel fully water soluble cationic porphyrin TMPy(3)PhenEDTA-P-Cl(4) in the dark, in the medullary thyroid carcinoma cell lines MTC-SK and SHER-I and weaker effects in the small intestinal neuroendocrine tumor cell line KRJ-I. In addition, cytotoxic effects were also studied in normal human fibroblasts that represent normal tissue and the results are compared to the tumor cell lines. Copyright © 2011 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents - pharmacology
- Apoptosis - drug effects
- Caspase 3 - metabolism
- Caspase 7 - metabolism
- Cell Line, Tumor -
- Edetic Acid - analogs & derivatives
- Humans -
- Neuroendocrine Tumors - pathology
- Porphyrins - chemistry
- Water - chemistry
- Find related publications in this database (Keywords)
- Cationic porphyrin
- Chelator
- Antitumor agent
- Human neuroendocrine tumor cells
- Medullary thyroid carcinoma cell lines
- Small intestinal carcinoma cell lines