Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Massone, C; Belachew, WA; Schettini, A.
Histopathology of the lepromatous skin biopsy.
Clin Dermatol. 2014; 33(1):38-45
Doi: 10.1016/j.clindermatol.2014.10.003
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Massone Cesare
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- Abstract:
- The histopathology of lepromatous skin varies according to the cell-mediated immunity of the host against Mycobacterium leprae. In tuberculoid and borderline tuberculoid leprosy, epithelioid noncaseating granulomas predominate, and acid-fast bacilli (AFB) are absent or only rarely present. In borderline lepromatous and lepromatous leprosy, the infiltrate is composed of macrophages with a vacuolar cytoplasm, lymphocytes, and plasma cells. AFB are numerous. Edema inside and outside the epithelioid granulomas, together with the appearance of large giant cells, are the main features of type 1 reactions. A conspicuous neutrophilic infiltrate in the subcutis with or without vasculitis is found in erythema nodosum leprosum. The main histopathologic features of leprosy and its particular forms are discussed in this review. Copyright © 2015 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Biopsy, Needle -
- Diagnosis, Differential -
- Disease Progression -
- Erythema Nodosum - pathology
- Erythema Nodosum - physiopathology
- Female -
- Humans -
- Immunohistochemistry -
- Leprosy, Borderline - pathology
- Leprosy, Borderline - physiopathology
- Leprosy, Lepromatous - pathology
- Leprosy, Lepromatous - physiopathology
- Leprosy, Tuberculoid - pathology
- Leprosy, Tuberculoid - physiopathology
- Male -
- Recurrence -
- Risk Assessment -
- Severity of Illness Index -
- Skin - pathology