Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Santos, AB; Kraigher-Krainer, E; Gupta, DK; Claggett, B; Zile, MR; Pieske, B; Voors, AA; Lefkowitz, M; Bransford, T; Shi, V; Packer, M; McMurray, JJ; Shah, AM; Solomon, SD; PARAMOUNT Investigators.
Impaired left atrial function in heart failure with preserved ejection fraction.
Eur J Heart Fail. 2014; 16(10):1096-1103
Doi: 10.1002/ejhf.147
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- Führende Autor*innen der Med Uni Graz
- Kraigher-Krainer Elisabeth
- Co-Autor*innen der Med Uni Graz
- Pieske Burkert Mathias
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- Abstract:
- Left atrial (LA) enlargement is present in the majority of heart failure with preserved ejection fraction (HFpEF) patients and is a marker of risk. However, the importance of LA function in HFpEF is less well understood. The PARAMOUNT trial enrolled HFpEF patients (LVEF ≥45%, NT-proBNP >400 pg/mL). We assessed LA reservoir, conduit, and pump function using two-dimensional volume indices and speckle tracking echocardiography in 135 HFpEF patients in sinus rhythm at the time of echocardiography and 40 healthy controls of similar age and gender. Systolic LA strain was related to clinical characteristics and measures of cardiac structure and function. Compared with controls, HFpEF patients had worse LA reservoir, conduit, and pump function. The differences in systolic LA strain (controls 39.2 ± 6.6% vs. HFpEF 24.6 ± 7.3%) between groups remained significant after adjustments and even in the subsets of HFpEF patients with normal LA size or without a history of AF. Among HFpEF patients, lower systolic LA strain was associated with higher prevalence of prior HF hospitalization and history of AF, as well as worse LV systolic function, and higher LV mass and LA volume. However, NT-proBNP and E/E' were similar across the quartiles of LA function. In this HFpEF cohort, we observed impairment in all phases of LA function, and systolic LA strain was decreased independent of LA size or history of AF. LA dysfunction may be a marker of severity and play a pathophysiological role in HFpEF. NCT00887588. © 2014 The Authors. European Journal of Heart Failure © 2014 European Society of Cardiology.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Atrial Function, Left -
- Echocardiography - methods
- Female -
- Heart Atria - pathology
- Heart Atria - physiopathology
- Heart Failure, Diastolic - diagnosis
- Heart Failure, Diastolic - physiopathology
- Humans -
- Male -
- Middle Aged -
- Organ Size -
- Prognosis -
- Risk Assessment -
- Risk Factors -
- Stroke Volume -
- Find related publications in this database (Keywords)
- Diastolic heart failure
- Echocardiography
- Atrial strain