Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cvirn, G; Waha, JE; Ledinski, G; Schlagenhauf, A; Leschnik, B; Koestenberger, M; Tafeit, E; Hinghofer-Szalkay, H; Goswami, N.
Bed rest does not induce hypercoagulability.
Eur J Clin Invest. 2015; 45(1):63-69
Doi: 10.1111/eci.12383
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Cvirn Gerhard
- Goswami Nandu
- Co-Autor*innen der Med Uni Graz
- Hinghofer-Szalkay Helmut
- Koestenberger Martin
- Ledinski Gerhard
- Leschnik Bettina
- Schlagenhauf Axel
- Tafeit Erwin
- Waha James Elvis
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- Abstract:
- Although there is no direct evidence, it is generally believed that bed rest shifts the haemostatic system towards hypercoagulability; thus, immobilized patients are commonly treated with anticoagulants. We therefore aimed to investigate whether long-term bed rest actually leads to an elevated risk for thromboembolic events. Eleven healthy men were enrolled in our study (bed rest campaign in MEDES Clinique d'Investigation, Toulouse, France). Besides various standard laboratory methods, we used calibrated automated thrombography (CAT) and thrombelastometry (TEM). Activation of samples with minute amounts of relipidated tissue factor allowed sensitive detection of hyper- or hypocoagulable states. CAT and TEM values were not indicative of bed rest-induced hypercoagulability. On the contrary, several parameters were indicative of a tendency towards a hypocoagulable state. Peak and thrombin formation velocity (VELINDEX) were significantly decreased during bed rest compared to baseline. Coagulation times were significantly increased and alpha angles were significantly decreased, indicating attenuated clot formation. Moreover, F1 + 2 and thrombin/antithrombin complex (TAT) values were significantly decreased during bed rest, indicating suppressed coagulation activation. FVII plasma levels were also significantly decreased during the first week of bed rest. Our data indicate that the re-ambulation period is associated with a tendency towards hypercoagulability: ttPeak and StartTail were significantly shorter, Peak and VELINDEX were significantly higher compared to baseline. Moreover, plasma levels of F1 + 2, TAT, FVII and FVIII were significantly higher compared to baseline. The results from our study suggest that bed rest by itself is not associated with hypercoagulable states in healthy subjects. © 2014 Stichting European Society for Clinical Investigation Journal Foundation.
- Find related publications in this database (using NLM MeSH Indexing)
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- Find related publications in this database (Keywords)
- Anticoagulants
- blood coagulation
- immobilization
- thrombelastography
- thrombin