Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Moscarella, E; Kyrgidis, A; Sperduti, I; Abramavicus, A; Argenziano, G; Cota, C; Eibenschutz, L; De Simone, P; Longo, C; Hofmann-Wellenhof, R; Zalaudek, I.
Age-related prevalence and morphological appearance of facial skin tumours: a prospective, cross-sectional, observational, multicentre study with special emphasis on melanocytic tumours.
J Eur Acad Dermatol Venereol. 2015; 29(7):1331-1338
Doi: 10.1111/jdv.12844
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Zalaudek Iris
- Co-Autor*innen der Med Uni Graz
- Hofmann-Wellenhof Rainer
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- Abstract:
- The clinical and histopathological diagnosis of skin tumours arising on the face may be challenging. An improved knowledge about the age-related patterns of facial skin tumours may aid the correct diagnosis and management. We conducted a prospective, cross-sectional morphological study to investigate the age-related frequency and morphological variability in facial skin tumours in a cohort of consecutive subjects attending two skin lesion clinics in Italy between June and September 2011. A total of 454 consecutive subjects (249 women; 55.5%) presenting with a total of 1866 facial tumours were enrolled in the study. Of the entire cohort, 54 (11.9%) subjects had no facial lesion. Total body naevus count correlated significantly with the mean number of facial lesions (ρ = 0.289, P < 0.001). The majority of flat lesions were pigmented (1056; 75.70%), compared to palpable (233; 17.40%) and raised lesions (93; 6.90%), the association being statistically significant (Pearson's chi square, P < 0.001. Considering melanocytic tumours only, the frequency of flat lesions significantly decreased with increasing age, while the number of palpable and raised lesions increased with increasing age (chi-square, P < 0.001). This trend was mainly due to naevi, whereby pigmented melanocytic naevi decreased with increasing age. Conversely, the percentage of non- pigmented naevi increased with increasing age (chi-square, P < 0.001). The study was conducted in skin lesion clinics in Italy, thus any general conclusions with respect to common traits or features based on the phenotypic and genetic diversity within the European population cannot be stated. Our study suggests that a high number of facial naevi could predict a high total naevus count. Moreover, naevi present a different morphological appearance during lifetime being initially flat, small and pigmented and becoming later raised, large and hypopigmented. Instead, lentigo maligna is an intraepidermal proliferation that typically presents as flat, large pigmented macule. A given histopathological diagnosis of a junctional naevus of a flat, facial pigmented macule of an elderly should be critically reviewed and treated with caution. © 2014 European Academy of Dermatology and Venereology.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Biopsy -
- Child -
- Child, Preschool -
- Cross-Sectional Studies -
- Facial Neoplasms - epidemiology
- Facial Neoplasms - pathology
- Female -
- Humans -
- Infant -
- Infant, Newborn -
- Infant, Newborn - epidemiology
- Male -
- Middle Aged -
- Nevus, Pigmented - epidemiology
- Nevus, Pigmented - pathology
- Prevalence -
- Prospective Studies -
- Skin - pathology
- Skin Neoplasms - epidemiology
- Skin Neoplasms - pathology
- Young Adult -