Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Regauer, S; Reich, O; Eberz, B.
Vulvar cancers in women with vulvar lichen planus: a clinicopathological study.
J Am Acad Dermatol. 2014; 71(4):698-707
Doi: 10.1016/j.jaad.2014.05.057
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- Führende Autor*innen der Med Uni Graz
- Regauer Sigrid
- Co-Autor*innen der Med Uni Graz
- Reich Olaf
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- Abstract:
- Vulvar squamous cell carcinomas (SCCs) arising in association with vulvar lichen planus (LP) are poorly documented. We sought to present clinicopathological features of 38 patients (median age 61 years, range 39-90 years) with LP-associated vulvar SCCs. Evaluated were location of vulvar SCC and metastases at presentation, recurrences, survival, precursor lesions, presence of human papillomavirus DNA, p16ink4a, and p53 expression. In all, 32 solitary (5 pT1a, 20 pT1b, 7 pT2) and 6 multifocal SCCs, located in the vestibulum (n=20) and in nonhair-bearing modified and glycogenated mucosa (n=18), arose in erosive (n=13) and nonerosive (n=25) LP. All SCCs were human papillomavirus DNA and p16ink4a negative. Sixteen of 38 (42%) women had inguinal metastases at presentation. Treatment was surgery with clear margins (36/38) and chemoradiation (2/38). Fourteen of 36 (39%) surgically treated patients developed between 1 and 5 new SCCs in the residual diseased mucosa. Of all recurrences, 68% developed within 12 months via precursors revealing various histologic features including elongated, but also flat rete ridges, basaloid and hypertrophic differentiation with inconsistent p53 expression. Fourteen of 38 (37%) patients died of SCCs. Retrospective study and lack of a standardized treatment protocols are limitations. LP-associated SCCs were located in nonhair-bearing vulvar mucosa. Patients had a high rate of inguinal metastases, recurrent vulvar cancers in diseased mucosa, and disease-related death. Copyright © 2014 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Biopsy, Needle -
- Carcinoma, Squamous Cell - complications
- Carcinoma, Squamous Cell - pathology
- Carcinoma, Squamous Cell - therapy
- Chemoradiotherapy -
- Cohort Studies -
- Combined Modality Therapy -
- Disease-Free Survival -
- Female -
- Gynecologic Surgical Procedures - methods
- Humans -
- Immunohistochemistry -
- Lichen Planus - complications
- Lichen Planus - pathology
- Lichen Planus - therapy
- Middle Aged -
- Neoplasm Invasiveness - pathology
- Neoplasm Recurrence, Local - epidemiology
- Neoplasm Recurrence, Local - pathology
- Neoplasm Recurrence, Local - therapy
- Prognosis -
- Retrospective Studies -
- Risk Assessment -
- Survival Analysis -
- Vulvar Diseases - complications
- Vulvar Diseases - pathology
- Vulvar Diseases - therapy
- Vulvar Neoplasms - complications
- Vulvar Neoplasms - pathology
- Vulvar Neoplasms - therapy
- Find related publications in this database (Keywords)
- differentiated vulvar intraepithelial neoplasia
- human papillomavirus-negative vulvar carcinoma
- precursor lesions
- vulvar dermatosis
- vulvar squamous cell carcinoma