Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hajnsek, M; Nacht, B; Sax, S; List, EJ; Klimant, I; Sinner, F.
The single-port concept: combining optical glucose measurement with insulin infusion.
Acta Diabetol. 2014; 51(5):883-886
Doi: 10.1007/s00592-014-0578-y
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Sinner Frank Michael
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- Abstract:
- The aim of this study was to develop a single-port system that combines glucose monitoring and insulin infusion. In a preclinical proof-of-concept trial, the performance of the glucose measurement at the site of insulin infusion was assessed. Glucose levels were clamped from 40 to 250 mg/dL by intravenous glucose infusion and subcutaneous insulin infusion via the glucose sensor. Sensor-glucose values correlated well with reference blood-glucose values, despite infusion at the site of glucose measurement. The average median ARE value was 21.6 ± 5.7 % for sensors used for insulin infusion, 18.1 ± 5.8 % for sensors used for NaCl infusion and 19.2 ± 7.9 % for sensors without infusion. These preclinical in vivo results demonstrate that single-port glucose monitoring is feasible at the site of insulin infusion.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Glucose - analysis
- Blood Glucose Self-Monitoring - instrumentation
- Blood Glucose Self-Monitoring - methods
- Drug Delivery Systems - instrumentation
- Drug Delivery Systems - methods
- Humans -
- Insulin - administration & dosage
- Insulin Infusion Systems -
- Find related publications in this database (Keywords)
- Continuous glucose monitoring
- Single-port system
- Optical glucose sensor
- Insulin infusion
- Preclinical trial