Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Domej, W; Oettl, K; Renner, W.
Oxidative stress and free radicals in COPD--implications and relevance for treatment.
Int J Chron Obstruct Pulmon Dis. 2014; 9(11):1207-1224
Doi: 10.2147/COPD.S51226
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- Führende Autor*innen der Med Uni Graz
- Domej Wolfgang
- Co-Autor*innen der Med Uni Graz
- Öttl Karl
- Renner Wilfried
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- Abstract:
- Oxidative stress occurs when free radicals and other reactive species overwhelm the availability of antioxidants. Reactive oxygen species (ROS), reactive nitrogen species, and their counterpart antioxidant agents are essential for physiological signaling and host defense, as well as for the evolution and persistence of inflammation. When their normal steady state is disturbed, imbalances between oxidants and antioxidants may provoke pathological reactions causing a range of nonrespiratory and respiratory diseases, particularly chronic obstructive pulmonary disease (COPD). In the respiratory system, ROS may be either exogenous from more or less inhalative gaseous or particulate agents such as air pollutants, cigarette smoke, ambient high-altitude hypoxia, and some occupational dusts, or endogenously generated in the context of defense mechanisms against such infectious pathogens as bacteria, viruses, or fungi. ROS may also damage body tissues depending on the amount and duration of exposure and may further act as triggers for enzymatically generated ROS released from respiratory, immune, and inflammatory cells. This paper focuses on the general relevance of free radicals for the development and progression of both COPD and pulmonary emphysema as well as novel perspectives on therapeutic options. Unfortunately, current treatment options do not suffice to prevent chronic airway inflammation and are not yet able to substantially alter the course of COPD. Effective therapeutic antioxidant measures are urgently needed to control and mitigate local as well as systemic oxygen bursts in COPD and other respiratory diseases. In addition to current therapeutic prospects and aspects of genomic medicine, trending research topics in COPD are presented.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antioxidants - therapeutic use
- Biomarkers - metabolism
- Disease Progression -
- Genetic Predisposition to Disease -
- Humans -
- Lung - drug effects
- Oxidative Stress - drug effects
- Pulmonary Disease, Chronic Obstructive - diagnosis
- Reactive Nitrogen Species - metabolism
- Reactive Oxygen Species - metabolism
- Risk Factors -
- Smoking - adverse effects
- Find related publications in this database (Keywords)
- reactive oxygen species
- reactive nitrogen species
- chronic obstructive pulmonary disease
- antioxidants