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Longo, C; Piana, S; Marghoob, A; Cavicchini, S; Rubegni, P; Cota, C; Ferrara, G; Cesinaro, AM; Baade, A; Bencini, PL; Mantoux, F; Mijuskovic, ZP; Pizzichetta, MA; Stanganelli, I; Carrera, C; Giovene, GL; Ranasinghe, S; Zalaudek, I; Lallas, A; Moscarella, E; Specchio, F; Pepe, P; Pellacani, G; Argenziano, G.
Morphological features of naevoid melanoma: results of a multicentre study of the International Dermoscopy Society.
Br J Dermatol. 2015; 172(4):961-967 Doi: 10.1111/bjd.13524
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Co-authors Med Uni Graz: Zalaudek Iris
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Abstract:: Naevoid melanoma (NeM), a rare variant of melanoma, can be difficult to detect as its clinical and histopathological morphology can simulate a naevus. To describe the clinical and dermoscopic features associated with NeM. Lesions with a histopathological diagnosis of NeM were collected via an e-mail request sent to all members of the International Dermoscopy Society. All lesions were histopathologically reviewed and only lesions fulfilling a set of predefined histopathological criteria were included in the study and analysed for their clinical and dermoscopic features. Twenty-seven of 58 cases (47%) fulfilled the predefined histopathological criteria for NeM and were included in the study. Clinically, 16 of the 27 NeMs presented as a nodular lesion (59%), eight (30%) as plaque type and three (11%) as papular. Analysis of the global dermoscopic pattern identified three types of NeM. The first were naevus-like tumours (n = 13, 48%), typified by a papillomatous surface resembling a dermal naevus. In these lesions local dermoscopic features included irregular dots/globules (46%), multiple milia-like cysts (38%) and atypical vascular structures (46%). The second type were amelanotic tumours (n = 8, 30%), typified by an atypical vascular pattern (75%). The third type consisted of tumours displaying a multicomponent pattern (n = 4, 15%), characterized by classical local melanoma-specific criteria. Two lesions (7%) were classified as mixed-pattern tumours as they did not manifest any of the aforementioned patterns. While NeMs may be clinically difficult to differentiate from naevi, any papillomatous lesion displaying dermoscopically atypical vessels and/or irregular dots/globules should prompt consideration for the possible diagnosis of NeM. © 2014 British Association of Dermatologists.
Find related publications in this database (using NLM MeSH Indexing): Dermoscopy -; Diagnosis, Differential -; Female -; Humans -; Male -; Middle Aged -; Nevus, Pigmented - pathology; Skin Neoplasms - pathology