Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bollen, L; Wibmer, C; Wang, M; van der Linden, YM; Leithner, A; Bünger, CE; Jensen, AB; Fiocco, M; Bratschitsch, G; Pondaag, W; Bovée, JV; Dijkstra, PD.
Molecular phenotype is associated with survival in breast cancer patients with spinal bone metastases.
Clin Exp Metastasis. 2015; 32(1):1-5
Doi: 10.1007/s10585-014-9685-y
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Bratschitsch Gerhard
- Leithner Andreas
- Wibmer Christine Linda
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- Abstract:
- To aid in therapy selection for patients with spinal bone metastases (SBM), predictive models have been developed. These models consider SBM from breast cancer a positive predictive factor, but do not take phenotypes based on estrogen (ER), progesterone (PR) and human epidermal growth factor 2 (HER2) receptors into account. The aim of this study was to ascertain whether receptors are associated with survival, when the disease has progressed up to SBM. All patients who were treated for SBM from breast cancer between 2005 and 2012 were included in this international multi-center retrospective study (n = 111). Reports were reviewed for ER, PR and HER2 status and subsequently subdivided into one of four categories; luminal A, luminal B, HER2 and triple negative. Survival time was calculated as the difference between start of treatment for SBM and date of death. Analysis was performed using the Kaplan-Meier method and log-rank tests. Median follow-up was 3.7 years. Survival times in the luminal B and HER2 categories were not significantly different to the luminal A category and were joined into a single receptor positive category. Eighty-five patients (77 %) had a receptor positive phenotype and 25 (23 %) had a triple negative phenotype. Median survival time was 22.5 months (95 %CI 18.0-26.9) for the receptor positive category and 6.7 months (95 %CI 2.4-10.9) for the triple negative category (p < 0.001). Patients with SBM from breast cancer with a triple negative phenotype have a shorter survival time than patients with a receptor positive phenotype. Models estimating survival should be adjusted accordingly.
- Find related publications in this database (using NLM MeSH Indexing)
- Biomarkers, Tumor - metabolism
- Disease-Free Survival -
- Female -
- Humans -
- Middle Aged -
- Phenotype -
- Receptor, ErbB-2 - metabolism
- Receptors, Estrogen - metabolism
- Receptors, Progesterone - metabolism
- Retrospective Studies -
- Spinal Neoplasms - mortality
- Spinal Neoplasms - secondary
- Triple Negative Breast Neoplasms - metabolism
- Triple Negative Breast Neoplasms - mortality
- Triple Negative Breast Neoplasms - pathology
- Find related publications in this database (Keywords)
- Spinal bone metastases
- Survival
- Breast cancer
- Molecular phenotype
- Receptor status