Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Friedrich, N; Schneider, HJ; Haring, R; Nauck, M; Völzke, H; Kroemer, HK; Dörr, M; Klotsche, J; Jung-Sievers, C; Pittrow, D; Lehnert, H; März, W; Pieper, L; Wittchen, HU; Wallaschofski, H; Stalla, GK.
Improved prediction of all-cause mortality by a combination of serum total testosterone and insulin-like growth factor I in adult men.
Steroids. 2012; 77(1-2):52-58
Doi: 10.1016/j.steroids.2011.10.005
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- März Winfried
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Lower levels of anabolic hormones in older age are well documented. Several studies suggested that low insulin-like growth factor I (IGF-I) or testosterone levels were related to increased mortality. The aim of the present study was to investigate the combined influence of low IGF-I and low testosterone on all-cause mortality in men. From two German prospective cohort studies, the DETECT study and SHIP, 3942 men were available for analyses. During 21,838 person-years of follow-up, 8.4% (n=330) of men died. Cox model analyses with age as timescale and adjusted for potential confounders revealed that men with levels below the 10th percentile of at least one hormone [hazard ratio (HR) 1.38 (95% confidence-interval (CI) 1.06-1.78), p=0.02] and two hormones [HR 2.88 (95% CI 1.32-6.29), p<0.01] showed a higher risk of all-cause mortality compared to men with non-low hormones. The associations became non-significant by using the 20th percentile as cut-off showing that the specificity increased with lower cut-offs for decreased hormone levels. The inclusion of both IGF-I and total testosterone in a mortality prediction model with common risk factors resulted in a significant integrated discrimination improvement of 0.5% (95% CI 0.3-0.7%, p=0.03). Our results prove that multiple anabolic deficiencies have a higher impact on mortality than a single anabolic deficiency and suggest that assessment of more than one anabolic hormone as a biomarker improve the prediction of all-cause mortality. Copyright © 2011 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aging - blood
- Follow-Up Studies -
- Follow-Up Studies - epidemiology
- Humans -
- Incidence -
- Insulin-Like Growth Factor I - analysis
- Insulin-Like Growth Factor I - deficiency
- Male -
- Middle Aged -
- Mortality - ethnology
- Predictive Value of Tests -
- Proportional Hazards Models -
- Prospective Studies -
- Risk Factors -
- Survival Analysis -
- Testosterone - blood
- Testosterone - deficiency
- Find related publications in this database (Keywords)
- IGF-1
- Testosterone
- Mortality
- Study of Health in Pomerania (SHIP)
- DETECT