Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hoffmann, MM; März, W; Genser, B; Drechsler, C; Wanner, C.
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and cardiovascular risk and efficacy of atorvastatin among subjects with diabetes on dialysis: the 4D study.
Atherosclerosis. 2011; 219(2):659-662
Doi: 10.1016/j.atherosclerosis.2011.07.126
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- We investigated whether KIF6 Trp719Arg genotypes affect cardiovascular outcomes and efficacy of statin therapy in patients with type 2 diabetes mellitus undergoing hemodialysis. We conducted a post hoc analysis of the 4D-study, a randomized trial including 1255 patients. Patients were randomly assigned to double-blind treatment with either 20mg of atorvastatin (n = 619) or placebo (n = 636) once daily and followed for 4 years (median). DNA was available for 1232 patients and we assessed KIF6 Trp719Arg genotypes by PCR and subsequent restriction digest. Carriers of the Arg719 allele showed no increased prevalence of cardiovascular disease. The incidence of cardiac death, MI, and stroke did not differ across KIF6 genotypes, irrespective of whether the patients were treated with atorvastatin or not. In patients with type 2 diabetes mellitus on hemodialysis, KIF6 Trp719Arg genotypes were not associated with adverse cardiovascular outcomes during follow-up or with the efficacy of atorvastatin therapy. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Analysis of Variance -
- Atherosclerosis - drug therapy
- Atherosclerosis - genetics
- Atherosclerosis - mortality
- Atorvastatin Calcium -
- Cardiovascular Diseases - genetics
- Cardiovascular Diseases - mortality
- Cardiovascular Diseases - prevention & control
- Diabetes Mellitus, Type 2 - complications
- Diabetes Mellitus, Type 2 - genetics
- Diabetes Mellitus, Type 2 - mortality
- Diabetes Mellitus, Type 2 - therapy
- Diabetic Angiopathies - drug therapy
- Diabetic Angiopathies - genetics
- Diabetic Angiopathies - mortality
- Diabetic Nephropathies - genetics
- Diabetic Nephropathies - mortality
- Diabetic Nephropathies - therapy
- Double-Blind Method -
- Female -
- Genetic Predisposition to Disease -
- Germany -
- Heptanoic Acids - therapeutic use
- Humans -
- Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
- Kinesin - genetics
- Logistic Models -
- Male -
- Middle Aged -
- Phenotype -
- Polymorphism, Genetic -
- Proportional Hazards Models -
- Prospective Studies -
- Pyrroles - therapeutic use
- Renal Dialysis - adverse effects
- Renal Dialysis - mortality
- Risk Assessment -
- Risk Factors -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- KIF6
- Pharmacogenetic
- Statin treatment
- Coronary artery disease
- Type 2 diabetes mellitus
- Hemodialysis