Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Silbernagel, G; Marz, W.
Plant sterols: Cardiovascular risk factors?
LABORATORIUMSMEDIZIN. 2008; 32(4): 209-218.
Doi: 10.1515/JLM.2008.040
Web of Science
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- Führende Autor*innen der Med Uni Graz
- März Winfried
- Silbernagel Günther
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- Abstract:
- Plant sterols are commonly used as cholesterol lowering nutriceuticals. In subjects who regularly consume plant sterol enriched functional foods, plasma plant sterol concentration is modestly increased. Sitosterolemia, a very rare genetic disorder, is characterized by xanthomas and up to 100-fold elevation of plasma plant sterols. Because patients with sitosterolemia are at high risk to develop severe premature coronary artery disease, even modestly increased plasma plant sterols are suggested to be atherogenic. Thus, there is no consensus on the question if cardiovascular risk can be reduced by the use of plant sterol margarines. In addition to their efficacy to decrease plasma cholesterol, plant sterols together with other non-cholesterol sterols are important for the investigation of cholesterol metabolism. Analyzing plasma non-cholesterol sterols, cholesterol absorption from the intestine and endogenous cholesterol biosynthesis can be estimated. The present review offers an overview of the topic "Plant Sterols". In particular, the role of plant sterols and cholesterol metabolism in atherogenesis is discussed. We focus on cholesterol metabolism, sitosterolemia, and the use of plant sterols as cholesterol lowering agents. Furthermore, the significance of plasma plant sterol measurement is explained.
- Find related publications in this database (Keywords)
- campesterol
- cholestanol
- cholesterol absorption
- cholesterol lowering
- cholesterol metabolism
- cholesterol synthesis
- functional food
- lathosterol
- plant sterols
- sitosterol
- sitosterolemia
- sterol margarine