Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schneider, HJ; Friedrich, N; Klotsche, J; Schipf, S; Nauck, M; Völzke, H; Sievers, C; Pieper, L; März, W; Wittchen, HU; Stalla, GK; Wallaschofski, H.
Prediction of incident diabetes mellitus by baseline IGF1 levels.
Eur J Endocrinol. 2011; 164(2):223-229
Doi: 10.1530/EJE-10-0963
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- März Winfried
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- Abstract:
- IGF1 is associated with metabolic parameters and involved in glucose metabolism. Low-IGF1 has been implicated in the etiology of glucose intolerance and subjects with pathological causes of either low- or high-IGF1 are at risk of diabetes. We hypothesized that both low- and high-IGF1 levels increase the risk of diabetes and aimed to assess the role of IGF1 in the risk of developing diabetes in a large prospective study. An analysis of two prospective cohort studies, the DETECT study and SHIP. We measured IGF1 levels in 7777 nondiabetic subjects and assessed incident diabetes mellitus during follow-up. There were 464 cases of incident diabetes during 32 229 person-years (time of follow-up in the DETECT study and SHIP: 4.5 and 5 years respectively). There was no heterogeneity between both studies (P > 0.4). The hazard ratios (HRs) of incident diabetes in subjects with IGF1 levels below the 10th or above the 90th age- and sex-specific percentile, compared to subjects with intermediate IGF1 levels, were 1.44 (95% confidence interval (CI) 1.07-1.94) and 1.55 (95% CI 1.06-2.06) respectively, after multiple adjustment. After further adjustment for metabolic parameters, the HR for low-IGF1 became insignificant. Analysis of IGF1 quintiles revealed a U-shaped association of IGF1 with risk of diabetes. Results remained similar after exclusion of patients with onset of new diabetes within 1 year or with borderline glucose or HbA1c levels at baseline. Subjects with low- or high-IGF1 level are at increased risk of developing diabetes.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Blood Glucose -
- Chi-Square Distribution -
- Diabetes Mellitus - blood
- Diabetes Mellitus - epidemiology
- Female -
- Follow-Up Studies -
- Humans -
- Incidence -
- Insulin-Like Growth Factor I -
- Male -
- Middle Aged -
- Predictive Value of Tests -
- Prospective Studies -
- Risk Factors -