Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Herbert, MK; Hering, S; Holzer, P.
Interleukin 1 beta, but not tumor necrosis factor, enhances neurogenic vasodilatation in the rat skin: involvement of nitric oxide.
CAN J PHYSIOL PHARMACOL 1995 73: 1075-1079.
Doi: 10.1139/y95-153
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Herbert Michael K.
- Co-Autor*innen der Med Uni Graz
- Holzer Peter
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- Abstract:
- In phenobarbitone-anesthetized rats the effects of interleukin 1 beta (IL-1 beta) and tumor necrosis factors (TNFs) were examined on the capsaicin-induced increase of plantar cutaneous blood flow in the rat hind paw as measured by laser Doppler flowmetry. IL-1 beta (0.5-500 pg) or TNF alpha or TNF beta (50-500 pg) was injected subcutaneously into the left paws, while the right paws received vehicle (10 microL) only. IL-1 beta was without effect on blood flow by its own but dose dependently enhanced the hyperemia due to capsaicin (0.3 microgram). TNFs failed to enhance the capsaicin-induced vasodilatation although 5000 pg TNF alpha produced a transient increase of local blood flow. Indomethacin (10 mg/kg, i.p.) did not alter the capsaicin-induced vasodilatation but prevented IL-1 beta (50 pg) from augmenting the hyperemic response to capsaicin. Likewise, blockade of nitric oxide formation by NG-nitro-L-arginine methyl ester (L-NAME) failed to affect the capsaicin-evoked vasodilatation but abolished its amplification by IL-1 beta. Systemic pretreatment with a neurotoxic dose of capsaicin reduced the capsaicin-induced hyperemia and prevented the facilitatory effect of IL-1 beta. The hyperemia evoked by intraplantar calcitonin gene related peptide (0.038-3.8 ng) was not altered by IL-1 beta (50 pg). These data indicate that IL-1 beta but not TNF enhances the cutaneous hyperemic response to capsaicin. This proinflammatory action arises from sensitization of afferent nerve endings and depends on nitric oxide and cyclooxygenase products as essential intermediates.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Arginine - analogs and derivatives
- Female - analogs and derivatives
- Interleukin-1 - pharmacology
- NG-Nitroarginine Methyl Ester - pharmacology
- Nitric Oxide - physiology
- Prostaglandins - physiology
- Rats - physiology
- Rats, Sprague-Dawley - physiology
- Regional Blood Flow - drug effects
- Research Support, Non-U.S. Gov't - drug effects
- Skin - blood supply
- Tumor Necrosis Factor-alpha - pharmacology
- Vasodilation - drug effects
- Find related publications in this database (Keywords)
- INTERLEUKIN 1-BETA
- TUMOR NECROSIS FACTOR
- CAPSAICIN
- NEUROGENIC INFLAMMATION
- NITRIC OXIDE