Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reineke, D; Winkler, B; König, T; Meszaros, K; Sodeck, G; Schönhoff, F; Erdoes, G; Czerny, M; Carrel, T.
Minimized extracorporeal circulation does not impair cognitive brain function after coronary artery bypass grafting.
Interact Cardiovasc Thorac Surg. 2015; 20(1):68-73
Doi: 10.1093/icvts/ivu341
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- Marsoner Katharina
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- Abstract:
- Objective evaluation of the impact of minimized extracorporeal circulation (MECC) on perioperative cognitive brain function in coronary artery bypass grafting (CABG) by electroencephalogram P300 wave event-related potentials and number connection test (NCT) as metrics of cognitive function. Cognitive brain function was assessed in 31 patients in 2013 with a mean age of 65 years [standard deviation (SD) 10] undergoing CABG by the use of MECC with P300 auditory evoked potentials (peak latencies in milliseconds) directly prior to intervention, 7 days after and 3 months later. Number connection test, serving as method of control, was performed simultaneously in all patients. Seven days following CABG, cognitive P300 evoked potentials were comparable with preoperative baseline values [vertex (Cz) 376 (SD 11) ms vs 378 (18) ms, P = 0.39; frontal (Fz) 377 (11) vs 379 (21) ms, P = 0.53]. Cognitive brain function at 3 months was compared with baseline values [(Cz) 376 (11) ms vs 371 (14 ms) P = 0.09; (Fz) 377 (11) ms vs 371 (15) ms, P = 0.04]. Between the first postoperative measurement and 3 months later, significant improvement was observed [(Cz) 378 (18) ms vs 371 (14) ms, P = 0.03; (Fz) 379 (21) vs 371 (15) ms, P = 0.02]. Similar clearly corresponding patterns could be obtained via the number connection test. Results could be confirmed in repeated measures analysis of variance for Cz (P = 0.05) and (Fz) results (P = 0.04). MECC does not adversely affect cognitive brain function after CABG. Additionally, these patients experience a substantial significant cognitive improvement after 3 months, evidentiary proving that the concept of MECC ensures safety and outcome in terms of brain function. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Brain - physiopathology
- Cognition -
- Cognition Disorders - diagnosis
- Cognition Disorders - etiology
- Cognition Disorders - physiopathology
- Cognition Disorders - prevention & control
- Cognition Disorders - psychology
- Coronary Artery Bypass - adverse effects
- Electroencephalography -
- Event-Related Potentials, P300 -
- Extracorporeal Circulation - adverse effects
- Extracorporeal Circulation - methods
- Female -
- Humans -
- Male -
- Middle Aged -
- Neuropsychological Tests -
- Predictive Value of Tests -
- Prospective Studies -
- Reaction Time -
- Recovery of Function -
- Risk Factors -
- Time Factors -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Coronary artery bypass grafting
- Brain function
- Minimized extracorporeal circulation circuit