Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lerchbaum, E; Schwetz, V; Rabe, T; Giuliani, A; Obermayer-Pietsch, B.
Hyperandrogenemia in polycystic ovary syndrome: exploration of the role of free testosterone and androstenedione in metabolic phenotype.
PLoS One. 2014; 9(10):e108263-e108263
Doi: 10.1371/journal.pone.0108263
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- Führende Autor*innen der Med Uni Graz
- Lerchbaum Elisabeth
- Co-Autor*innen der Med Uni Graz
- Giuliani Albrecht
- Obermayer-Pietsch Barbara
- Theiler-Schwetz Verena
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- Abstract:
- To evaluate the association between androstenedione, testosterone, and free testosterone and metabolic disturbances in polycystic ovary syndrome. We analyzed the association between androstenedione, testosterone, and free testosterone and metabolic parameters in a cross-sectional study including 706 polycystic ovary syndrome and 140 BMI-matched healthy women. Polycystic ovary syndrome women were categorized into 4 groups: normal androstenedione and normal free testosterone (NA/NFT), elevated androstenedione and normal free testosterone (HA/NFT), normal androstenedione and elevated free testosterone (NA/HFT), elevated androstenedione and free testosterone (HA/HFT). Polycystic ovary syndrome women with elevated free testosterone levels (HA/HFT and NA/HFT) have an adverse metabolic profile including 2 h glucose, HbA1c, fasting and 2 h insulin, area under the insulin response curve, insulin resistance, insulin sensitivity index (Matsuda), triglycerides, total and high density lipoprotein cholesterol levels compared to NA/NFT (p<0.05 for all age- and BMI-adjusted analyses). In binary logistic regression analysis adjusted for age and BMI, odds ratio for insulin resistance was 2.78 (1.34-5.75, p = 0.006) for polycystic ovary syndrome women with HA/HFT compared to NA/NFT. We found no significantly increased risk of metabolic disorders in polycystic ovary syndrome women with HA/NFT. In multiple linear regression analyses (age- and BMI-adjusted), we found a significant negative association between androstenedione/free testosterone-ratio and area under the insulin response curve, insulin resistance, and total cholesterol/high density lipoprotein cholesterol-ratio and a positive association with Matsuda-index, and high density lipoprotein cholesterol (p<0.05 for all). Polycystic ovary syndrome women with elevated free testosterone levels but not with isolated androstenedione elevation have an adverse metabolic phenotype. Further, a higher androstenedione/free testosterone-ratio was independently associated with a beneficial metabolic profile.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Androstenedione - blood
- Blood Glucose - metabolism
- Body Mass Index -
- Cross-Sectional Studies -
- Fasting - blood
- Female -
- Humans -
- Hyperandrogenism - blood
- Insulin - blood
- Middle Aged -
- Polycystic Ovary Syndrome - blood
- Testosterone - blood
- Young Adult -