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Herbert, MK; Holzer, P.
Interleukin-1 beta enhances capsaicin-induced neurogenic vasodilatation in the rat skin.
BRIT J PHARMACOL 1994 111: 681-686. Doi: 10.1111/j.1476-5381.1994.tb14791.x [OPEN ACCESS]
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Leading authors Med Uni Graz: Herbert Michael K.
Co-authors Med Uni Graz: Holzer Peter
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Abstract:: 1. This study examined the effect of interleukin-1 beta (IL-1 beta) on the capsaicin-induced increase in cutaneous blood flow of anaesthetized rats as measured by laser Doppler flowmetry. 2. The substances were administered by intraplantar subcutaneous injection of 10 microliters-volumes, saline being injected into one hindpaw and IL-1 beta into the other. 3. IL-1 beta (0.5-500 pg) was without effect on blood flow on its own but dose-dependently enhanced the hyperaemic response to intraplantar capsaicin (0.3 microgram) up to 180% (P < 0.05) of the response seen in saline-treated paws. 4. Il-1 beta-(163-171), a fragment devoid of proinflammatory activity, failed to enhance capsaicin-induced hyperaemia when given at a dose of 50 pg. 5. Indomethacin (10 mg kg-1, i.p.) did not alter the capsaicin-induced vasodilatation but prevented IL-1 beta (50 pg) from augmenting the hyperaemic response to capsaicin. 6. The hyperaemia evoked by intraplantar calcitonin gene-related peptide (0.038-3.8 ng) was not altered by IL-1 beta (50 pg). 7. These data indicate that IL-1 beta enhances the cutaneous hyperaemic response to afferent nerve stimulation with capsaicin in a prostaglandin-dependent manner. This proinflammatory action of the cytokine appears to arise from sensitization of afferent nerve endings.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Blood Pressure - drug effects; Calcitonin Gene-Related Peptide - pharmacology; Capsaicin - pharmacology; Drug Synergism - pharmacology; Female - pharmacology; Hyperemia - chemically induced; Indomethacin - pharmacology; Interleukin-1 - pharmacology; Muscle, Smooth, Vascular - drug effects; Neurons, Afferent - drug effects; Rats - drug effects; Rats, Sprague-Dawley - drug effects; Research Support, Non-U.S. Gov't - drug effects; Skin - blood supply; Stimulation, Chemical - blood supply; Vasodilation - drug effects
Find related publications in this database (Keywords): Interleukin-1-Beta; Capsaicin; Afferent Nerve Stimulation; Cutaneous Hyperemia; Neurogenic Inflammation; Sensitization of Afferent Nerve Endings; Proinflammatory Action; Prostaglandins; Calcitonin Gene-Related Peptide (CGRP)