Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Olschewski, A; Papp, R; Nagaraj, C; Olschewski, H.
Ion channels and transporters as therapeutic targets in the pulmonary circulation.
Pharmacol Ther. 2014; 144(3):349-368
Doi: 10.1016/j.pharmthera.2014.08.001
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Olschewski Andrea
- Co-Autor*innen der Med Uni Graz
- Chandran Nagaraj
- Olschewski Horst
- Papp Rita
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- Abstract:
- Pulmonary circulation is a low pressure, low resistance, high flow system. The low resting vascular tone is maintained by the concerted action of ion channels, exchangers and pumps. Under physiological as well as pathophysiological conditions, they are targets of locally secreted or circulating vasodilators and/or vasoconstrictors, leading to changes in expression or to posttranslational modifications. Both structural changes in the pulmonary arteries and a sustained increase in pulmonary vascular tone result in pulmonary vascular remodeling contributing to morbidity and mortality in pediatric and adult patients. There is increasing evidence demonstrating the pivotal role of ion channels such as K(+) and Cl(-) or transient receptor potential channels in different cell types which are thought to play a key role in vasoconstrictive remodeling. This review focuses on ion channels, exchangers and pumps in the pulmonary circulation and summarizes their putative pathophysiological as well as therapeutic role in pulmonary vascular remodeling. A better understanding of the mechanisms of their actions may allow for the development of new options for attenuating acute and chronic pulmonary vasoconstriction and remodeling treating the devastating disease pulmonary hypertension. Copyright © 2014 Elsevier Inc. All rights reserved.
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- Ion Channels - genetics
- Ion Channels - metabolism
- Ion Pumps - antagonists & inhibitors
- Ion Pumps - genetics
- Ion Pumps - metabolism
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- Ion channels
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