Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hrzenjak, A; Dieber-Rotheneder, M; Moinfar, F; Petru, E; Zatloukal, K.
Molecular mechanisms of endometrial stromal sarcoma and undifferentiated endometrial sarcoma as premises for new therapeutic strategies.
Cancer Lett. 2014; 354(1):21-27
Doi: 10.1016/j.canlet.2014.08.013
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Dieber-Rotheneder Martina
- Hrzenjak Andelko
- Co-Autor*innen der Med Uni Graz
- Moinfar Farid
- Petru Edgar
- Zatloukal Kurt
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- Abstract:
- Endometrial stromal sarcoma (ESS) and undifferentiated endometrial sarcoma (UES) are very rare gynecologic malignancies. Due to the rarity and heterogeneity of these tumors, little is known about their epidemiology, pathogenesis, and molecular pathology. Our previous studies have described deregulation of histone deacetylases expression in ESS/UES samples. Some of these enzymes can be inhibited by substances which are already approved for treatment of cutaneous T-cell lymphoma. On the basis of published data, they may also provide a therapeutic option for ESS/UES patients. Our review focuses on molecular mechanisms of ESS/UES. It describes various aspects with special emphasis on alteration of histone deacetylation and its possible relevance for novel therapies. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Acetylation -
- Cell Differentiation -
- Endometrial Neoplasms - genetics
- Endometrial Neoplasms - metabolism
- Endometrial Stromal Tumors - genetics
- Endometrial Stromal Tumors - metabolism
- Female -
- Gene Expression Regulation, Neoplastic -
- Histone Deacetylase Inhibitors - chemistry
- Histone Deacetylases - metabolism
- Histones - chemistry
- Humans -
- Lymphoma, T-Cell, Cutaneous - metabolism
- Sarcoma, Endometrial Stromal - genetics
- Sarcoma, Endometrial Stromal - metabolism
- Treatment Outcome -
- Wnt Proteins - metabolism
- Find related publications in this database (Keywords)
- Mesenchymal uterine tumors
- Endometrial stromal sarcomas
- Chemotherapy
- Histone deacetylase inhibitors
- Vorinostat