Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cramer, L; Hildebrandt, B; Kung, T; Wichmann, K; Springer, J; Doehner, W; Sandek, A; Valentova, M; Stojakovic, T; Scharnagl, H; Riess, H; Anker, SD; von Haehling, S.
Cardiovascular function and predictors of exercise capacity in patients with colorectal cancer.
J Am Coll Cardiol. 2014; 64(13):1310-1319
Doi: 10.1016/j.jacc.2014.07.948
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- Co-Autor*innen der Med Uni Graz
- Scharnagl Hubert
- Stojakovic Tatjana
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- Abstract:
- Patients with colorectal cancer (CRC) often present with dyspnea and fatigue. These are also frequent symptoms in patients with chronic heart failure (CHF). We hypothesized that similar patterns of cardiovascular perturbations are present in CRC and CHF. We prospectively studied 50 patients with CRC, 51 patients with CHF, and 51 control subjects. The CRC group was divided into 2 subgroups: patients who underwent chemotherapy (n = 26) and chemotherapy-naive patients (n = 24). We assessed exercise capacity (spiroergometry), cardiac function (echocardiography), heart rate variability (Holter electrocardiography), body composition (dual-energy x-ray absorptiometry), and blood parameters. Compared with the control arm, the left ventricular ejection fraction (CRC group 59.4%; control group 62.5%) and exercise performance as assessed by peak oxygen consumption (peak VO2) (CRC group 21.8 ml/kg/min; control group 28.0 ml/kg/min) were significantly reduced in CRC patients (both p < 0.02). Markers of heart rate variability were markedly impaired in CRC patients compared with control subjects (all p < 0.008). Compared with the control group, the CRC group also showed reduced lean mass in the legs and higher levels of the endothelium-derived C-terminal-pro-endothelin-1 (both p < 0.02). Major determinants of cardiovascular function were impaired in chemotherapy-treated patients and in the chemotherapy-naive patients, particularly with regard to exercise capacity, left ventricular ejection fraction, lean mass, and heart rate variability (all p < 0.05 vs. control subjects). Some aspects of cardiovascular function are impaired in patients with CRC. More importantly, our findings were evident independently of whether patients were undergoing chemotherapy. Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Absorptiometry, Photon -
- Aged -
- Antineoplastic Agents - therapeutic use
- Body Composition -
- Cardiovascular System - physiopathology
- Colorectal Neoplasms - physiopathology
- Dyspnea - physiopathology
- Echocardiography -
- Ergometry -
- Exercise -
- Exercise Tolerance - physiology
- Fatigue - physiopathology
- Female -
- Heart Failure - physiopathology
- Heart Rate -
- Humans -
- Male -
- Middle Aged -
- Oxygen Consumption -
- Prospective Studies -
- Ventricular Function, Left -
- Find related publications in this database (Keywords)
- cardiovascular function
- colorectal cancer
- exercise capacity