Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wolf, EM; Plieschnegger, W; Schmack, B; Bordel, H; Höfler, B; Eherer, A; Schulz, T; Vieth, M; Langner, C.
Evolving patterns in the diagnosis of reactive gastropathy: data from a prospective Central European multicenter study with proposal of a new histologic scoring system.
Pathol Res Pract. 2014; 210(12):847-854
Doi: 10.1016/j.prp.2014.08.009
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Langner Cord
- Co-Autor*innen der Med Uni Graz
- Eherer Andreas
- Höfler Bernd
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Histologic examination of gastric biopsies is crucial for determining the cause of gastritis. This prospective multicenter study was undertaken to investigate different histologic parameters arguing in favor or against the diagnosis of reactive gastropathy and to correlate findings with patient's symptoms and endoscopic findings. A total of 1123 individuals aged 15-93 years participated in a prospective multicenter study (histoGERD trial). Diagnosis of Helicobacter gastritis was made following the Updated Sydney System. Diagnosis of reactive gastropathy was based upon Dixon's parameters of foveolar hyperplasia, smooth muscle fibers in the lamina propria and vasodilatation and congestion of mucosal capillaries. Including paucity of acute and chronic inflammatory cells in analysis, a new score with visual analog scales for the diagnosis of reactive gastropathy was developed. All three histologic parameters in favor of the diagnosis of reactive gastropathy were positively associated with the endoscopic diagnosis of gastritis (p < 0.001), yet negatively with Helicobacter infection (p < 0.001). In contrast, presence of acute and chronic inflammatory cells in lamina propria was positively associated with Helicobacter infection (p < 0.001), yet not with the endoscopic diagnosis of gastritis. Our score demonstrated strong association between histologic and endoscopic diagnoses (p < 0.001), yet not with patient's symptoms. In conclusion, our data prove foveolar hyperplasia, smooth muscle fibers and vasodilatation and congestion as key histologic parameters for the diagnosis of reactive gastropathy. The proposed score may enhance the diagnostic accuracy. It should be validated in future studies. Copyright © 2014 Elsevier GmbH. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Aged, 80 and over -
- Biopsy -
- Chronic Disease -
- Female -
- Gastritis - microbiology Gastritis - pathology
- Gastroscopy -
- Gastroscopy -
- Helicobacter Infections - microbiology Helicobacter Infections - pathology
- Helicobacter pylori - isolation & purification
- Humans -
- Hyperplasia -
- Male -
- Middle Aged -
- Myocytes, Smooth Muscle - pathology
- Predictive Value of Tests -
- Prospective Studies -
- Risk Factors -
- Stomach - microbiology Stomach - pathology
- Vasodilation -
- Young Adult -
- Find related publications in this database (Keywords)
- Chronic gastritis
- Reflux gastritis
- Endoscopy
- Histology
- Visual analog scale