Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gutmann, A; Krump, C; Bungaruang, L; Nidetzky, B.
A two-step O- to C-glycosidic bond rearrangement using complementary glycosyltransferase activities.
Chem Commun (Camb). 2014; 50(41):5465-5468
Doi: 10.1039/c4cc00536h
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- Co-Autor*innen der Med Uni Graz
- Krump Corinna
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- Abstract:
- An efficient 2'-O- to 3'-C-β-d-glucosidic bond rearrangement on the dihydrochalcone phloretin to convert phlorizin into nothofagin was achieved by combining complementary O-glycosyltransferase (OGT) and C-glycosyltransferase (CGT) activities in a one-pot transformation containing catalytic amounts of uridine 5'-diphosphate (UDP). Two separate enzymes or a single engineered dual-specific O/CGT were applied. Overall (quantitative) conversion occurred in two steps via intermediary UDP-glucose and phloretin.
- Find related publications in this database (using NLM MeSH Indexing)
- Carbon - chemistry
- Glycosides - chemistry
- Glycosyltransferases - metabolism
- Oryza - enzymology
- Oxygen - chemistry
- Pyrus - enzymology
- Substrate Specificity -